An update on liver transplantation: A critical review

Journal of Autoimmunity
J Neuberger

Abstract

Liver transplantation, although now a routine procedure, with defined indications and usually excellent outcomes, still has challenges. Donor shortage remains a key issue. Transplanted organs are not free of risk and may transmit cancer, infection, metabolic or autoimmune disease. Approaches to the donor shortage include use of organs from donors after circulatory death, from living donors and from those previously infected with Hepatitis B and C and even HIV for selected recipients. Normothermic regional and/or machine perfusion, whether static or pulsatile, normo- or hypothermic, are being explored and will be likely to have a major place in improving donation rates and outcomes. The main indications for liver replacement are alcoholic liver disease, HCV, non-alcoholic liver disease and liver cancer. Recent studies have shown that selected patients with severe alcoholic hepatitis may also benefit from liver transplant. The advent of new and highly effective treatments for HCV, whether given before or after transplant will have a major impact on outcomes. The role of transplantation for those with liver cell cancer continues to evolve as other interventions become more effective. Immunosuppression is usually required life-long...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Mar 3, 1998·Lancet·N KerkarG Mieli-Vergani
Sep 30, 2006·Gut·K BarberUNKNOWN UK Transplant Liver Advisory Group
Jan 30, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Ian A RoweJames Neuberger
Mar 14, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B FreemanR M Merion
Aug 21, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Ilona T A PereboomRobert J Porte
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael R CharltonUNKNOWN International Liver Transplantation Society Expert Panel
Dec 3, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P BurraUNKNOWN ELTR Liver Transplant Centers
Jul 27, 2010·Lancet·Debbie L Shawcross, John G O'Grady
Mar 9, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Patrizia BurraMarco Senzolo
Sep 8, 2011·Current Opinion in Organ Transplantation·Ruben CiriaNigel Heaton
Nov 4, 2011·The Lancet Oncology·Pierre-Alain ClavienUNKNOWN OLT for HCC Consensus Group
Nov 11, 2011·The New England Journal of Medicine·Philippe MathurinJean-Charles Duclos-Vallée
Jan 4, 2012·British Journal of Anaesthesia·A R ManaraG O'Callaghan
Apr 14, 2012·Current Opinion in Organ Transplantation·M Isabel Fiel, Thomas D Schiano
Feb 26, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M CarboneJ M Neuberger
Jul 23, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rodrigo LiberalDiego Vergani
Sep 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Castillo-RamaA J Demetris
May 31, 2014·World Journal of Gastroenterology : WJG·Rajeev Desai, James Neuberger
Jun 20, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Evangelos CholongitasPatrizia Burra
Sep 28, 2014·Journal of Autoimmunity·Aftab A Ansari
Dec 3, 2014·Journal of Autoimmunity·Andrea T BorchersM Eric Gershwin
Dec 17, 2014·Transplantation Reviews·C K BurghuberS J Knechtle
Jan 8, 2015·Current Opinion in Organ Transplantation·Sotiris MastoridisKathryn J Wood
Jan 23, 2015·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Martin I MontenovoRyan N Hansen
Mar 15, 2015·Transplantation Proceedings·A HudaC O Esquivel
Apr 16, 2015·Journal of the American College of Surgeons·Kristopher P CroomeDavid M Nagorney
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Apr 29, 2015·Journal of Hepatology·Stuart J ForbesAnil Dhawan
May 16, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A RichtermanE A Blumberg
Jun 19, 2015·World Journal of Hepatology·Christina HacklMartin Loss
Jun 23, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A GalanteM Sterneck
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN AASLD/IDSA HCV Guidance Panel
Jul 4, 2015·World Journal of Hepatology·Chrysoula Pipili, Evangelos Cholongitas
Jul 15, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John C MansourJean-Nicolas Vauthey
Jul 24, 2015·Hepatology International·Moana Gelu-SimeonDidier Samuel
Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·N LaverdureA Lachaux
Jul 30, 2015·The New England Journal of Medicine·Claus U NiemannDarren Malinoski
Dec 31, 2015·The New England Journal of Medicine·Claus U Niemann, Darren Malinoski

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Citations

Dec 15, 2016·Paediatrics and International Child Health·Michael France
Jan 10, 2018·Clinical Reviews in Allergy & Immunology·Min LianXiong Ma
Sep 12, 2019·Journal of Clinical Medicine·Maria Irene BelliniVassilios Papalois
Sep 29, 2019·International Journal of Laboratory Hematology·Akbar DorgalalehHojat Shahreki
Feb 25, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Katelynn Madill-ThomsenPhilip F Halloran
Aug 10, 2018·World Journal of Gastroenterology : WJG·Isabel AguileraAntonio Nuñez-Roldan
Aug 23, 2020·International Journal of Molecular Sciences·Raji BaidyaKim R Bridle
Feb 24, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A KramerJ C Harnoss
May 7, 2019·World Journal of Gastroenterology : WJG·Tao MaRong-Qian Wu
Jul 14, 2020·Frontiers in Immunology·Angus HannM Thamara P R Perera
Aug 9, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ajay K JainSimon Horslen
Sep 4, 2020·Frontline Gastroenterology·Charles MillsonDhiraj Tripathi
Jun 13, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiLinda Henry
Nov 16, 2020·Asian Journal of Surgery·Ahmed AbdallahWalid Rafat Abdelaty
Oct 17, 2020·Middle East Journal of Digestive Diseases·Niloofar Razavi-KhorasaniMohssen Nassiri Toosi
Jan 22, 2021·Molecular Therapy. Methods & Clinical Development·Giulia De SabbataAndrés F Muro
Aug 16, 2017·The Journal of Surgical Research·Chunyi KanMichael Boettcher
Jan 9, 2021·Transplantation·Xinle WangCatia T Perciani
Nov 16, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Reyhane Hizomi AraniMohammad Hossein Shojamoradi

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