An update on papillary microcarcinoma

Current Opinion in Oncology
Simon Grodski, Leigh Delbridge

Abstract

There is a worldwide increasing incidence of thyroid cancer, mostly due to the increased diagnosis of papillary microcarcinoma (PMC). This review examines its clinical significance and optimal treatment. It is unclear whether or not the increase in PMC is real, or is simply due to the increased detection and diagnosis. The increase has been attributed to the widespread availability of thyroid ultrasound, with increasing numbers of clinically insignificant thyroid nodules subject to fine needle aspiration biopsy and surgical excision. An additional explanation is simply an increase in the number of routine histologic sections taken from the thyroidectomy specimens over the years. There have been two recent large clinical series with long-term follow-up highlighting the excellent prognosis of PMC. Novel research into immunohistochemical markers and advanced imaging with fluorodeoxyglucose positron emission tomography aims to identify the markers of more aggressive PMC. Management of PMC remains controversial, from observation alone to total thyroidectomy/radioiodine ablation. PMC has been increasing rapidly over recent decades due to increased cervical ultrasound and increased detection in pathological specimens. There is no comp...Continue Reading

References

Dec 1, 1996·The British Journal of Surgery·M D Bramley, B J Harrison
Jun 14, 2003·Thyroid : Official Journal of the American Thyroid Association·Yasuhiro ItoAkira Miyauchi
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Gabriella PellegritiAntonino Belfiore
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May 27, 2006·European Journal of Endocrinology·Furio PaciniUNKNOWN European Thyroid Cancer Taskforce
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Oct 25, 2007·Thyroid : Official Journal of the American Thyroid Association·Dong-Jun LimSung-Koo Kang
Feb 12, 2008·World Journal of Surgery·Shiro NoguchiShin Watanabe

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Citations

Oct 20, 2011·Thyroid : Official Journal of the American Thyroid Association·Matteo LandriscinaMauro Cignarelli
Aug 27, 2010·Annals of Surgical Oncology·T T Law, Brian Hung-Hin Lang
Apr 10, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Davor DžepinaHrvoje Čupić
Aug 26, 2014·Surgery·Jessica PreeceJonathan Serpell
Jan 15, 2013·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Sebastian R AspinallThomas W J Lennard
Oct 20, 2009·The Surgical Clinics of North America·James Suliburk, Leigh Delbridge
Apr 6, 2012·European Annals of Otorhinolaryngology, Head and Neck Diseases·J-C RissA Bozec
Oct 29, 2013·Endocrine-related Cancer·Federica MoraniCiro Isidoro
May 9, 2012·Journal of the Korean Surgical Society·Jin-Kyu ChoSang-Kyung Choi

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