An update on smart biocatalysts for industrial and biomedical applications

Journal of the Royal Society, Interface
Akhilesh Kumar Shakya, Kutty Selva Nandakumar

Abstract

Recently, smart biocatalysts, where enzymes are conjugated to stimuli-responsive (smart) polymers, have gained significant attention. Based on the presence or absence of external stimuli, the polymer attached to the enzyme changes its conformation to protect the enzyme from the external environment and regulate the enzyme activity, thus acting as a molecular switch. Owing to this behaviour, smart biocatalysts can be separated easily from a reaction mixture and re-used several times. Several such smart polymer-based biocatalysts have been developed for industrial and biomedical applications. In addition, they have been used in biosensors, biometrics and nano-electronic devices. This review article covers recent advances in developing different kinds of stimuli-responsive enzyme bioconjugates, including conjugation strategies, and their applications.

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Citations

May 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gregor KravanjaMaja Leitgeb
Apr 8, 2020·Biotechnology and Bioengineering·Adam A CaparcoJulie A Champion
Jul 24, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Dilek NartopNurşen Sarı
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Dec 28, 2021·Chembiochem : a European Journal of Chemical Biology·Weifu DongZhongyang Ding

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