An update on the role of medical treatment including antioxidant therapy in varicocele

Asian Journal of Andrology
Harshit Garg, Rajeev Kumar

Abstract

Varicocele-associated male infertility has classically been managed using surgery or assisted reproductive techniques. With increasing evidence of oxidative stress as a pathophysiological factor in varicocele-associated infertility, medical therapy especially antioxidants might become a treatment option with lower risks. We reviewed the existing literature on the role of various medical agents in the management of male infertility attributed to varicoceles. Medical therapy is typically evaluated in three different situations such as (a) comparison of two drugs or one drug with placebo, (b) comparison of drugs versus surgery, and (c) comparison of drugs as adjuvant therapy with surgery versus drug therapy alone. Due to heterogeneity of data and lack of well-conducted studies, there is insufficient data to recommend routine use of medical therapy for men with varicocele-associated infertility and surgery remains the treatment of choice. Pregnancy and live birth rates are usually not reported in most studies and mere improvement in sperm parameters or antioxidant capacity is insufficient to support its routine use. Antioxidant therapy is a potential option due to its theoretical benefit, data from preclinical studies, and lack of ...Continue Reading

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Citations

Jan 20, 2016·Asian Journal of Andrology·Ashok Agarwal, Sandro C Esteves
Jan 20, 2016·Asian Journal of Andrology·Sandro C Esteves, Ashok Agarwal
Apr 14, 2016·Asian Journal of Andrology·Joshua D RingTobias S Köhler
May 13, 2018·BJU International·Parisa MohammadiMohammad H Nasr-Esfahani
Jul 25, 2018·Andrologia·Erfaneh ShayganniaMohammad H Nasr-Esfahani
Nov 27, 2018·Andrologia·Rana Ghandehari-AlavijehMohammad H Nasr-Esfahani
Mar 14, 2019·The Cochrane Database of Systematic Reviews·Roos M SmitsMarian G Showell
Oct 1, 2019·Medicine·Xiaojiang YuChaojie Yang
Mar 28, 2017·Journal of Assisted Reproduction and Genetics·Jaime GosalvezAshok Agarwal
Mar 15, 2019·Scientific Reports·Sahar TahamtanMohammad Hosseini Nasr-Esfahani
May 19, 2018·The World Journal of Men's Health·Sunghyun Paick, Woo Suk Choi
Oct 10, 2020·Reproductive Biomedicine Online·Behzad AbbasiMohammad H Nasr-Esfahani

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