An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets

PeerJ
Dimitrios VlachakisElias Eliopoulos

Abstract

Notch family proteins play a key role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis, neurogenesis and homeostasis. The Notch signaling pathway is crucial for the majority of developmental programs and regulates multiple pathogenic processes. Notch family receptors' activation has been largely related to its multiple effects in sustaining oncogenesis. The Notch signaling pathway constitutes an ancient and conserved mechanism for cell to cell communication. Much of what is known about Notch family proteins function comes from studies done in Caenorhabditis Elegans and Drosophila Melanogaster. Although, human Notch homologs had also been identified, the molecular mechanisms which modulate the Notch signaling pathway remained substantially unknown. In this study, an updated evolutionary analysis of the Notch family members among 603 different organisms of all kingdoms, from bacteria to humans, was performed in order to discover key regions that have been conserved throughout evolution and play a major role in the Notch signaling pathway. The major goal of this study is t...Continue Reading

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Citations

Feb 13, 2021·International Journal of Molecular Sciences·Tobias M BallhauseJohannes Keller
May 27, 2021·Biology of the Cell·Ekaterina Seib, Thomas Klein

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Methods Mentioned

BETA
electron microscopy
glycosylation

Software Mentioned

MATLAB
TreeExplorer
MATLAB Bioinformatics Toolbox
MEGA
JalView

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