An updated insight into the molecular pathogenesis, secondary complications and potential therapeutics of COVID-19 pandemic

Life Sciences
Sumit JamwalPuneet Kumar

Abstract

Coronavirus disease 2019 (COVID-19) is an unprecedented disease caused by highly pathogenic SARS-CoV-2 and characterized by extreme respiratory deterrence, pneumonia and immune damage. The phylogenetic analysis demonstrated the sequence similarity of SARS-CoV-2 with other SARS-like bat viruses. The primary source and intermediate host are not yet confirmed, although transmission from human to human is universally confirmed. The new SARS-CoV-2 virus reaches cells via ACE-2 and subsequently down-regulates ACE-2, leaving angiotensin II unbalanced in affected organs primarily in the lungs, heart, brain, and kidneys. As reported recently, numerous secondary complications i.e., neurological, nephrological, cardiovascular, gastrointestinal, immune, and hepatic complications, are associated with COVID-19 infection along with prominent respiratory disease including pneumonia. Extensive research work on recently discovered SARS-CoV-2 is in the pipeline to clarify pathogenic mechanisms, epidemiological features, and identify new drug targets that will lead to the development of successful strategies for prevention and treatment. There are currently no appropriate scientifically approved vaccines/drugs for COVID-19. Nonetheless, few broad-...Continue Reading

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Citations

Sep 16, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Dushyant Singh DahiyaFarah Wani
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Methods Mentioned

BETA
RNA-seq
surface plasmon resonance
biopsy
glycosylation

Clinical Trials Mentioned

NCT04261517
NCT04276688
NCT04343768
NCT04358614
NCT04291729
NCT04244591
NCT04336904
NCT04349241
NCT04346628
NCT04310228

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