An updated meta-analysis of TAVR in patients at intermediate risk for SAVR

Cardiovascular Revascularization Medicine : Including Molecular Interventions
Mohamad LazkaniAshish Pershad

Abstract

Transcatheter aortic valve replacement (TAVR) has been approved for use in patients with severe aortic stenosis at intermediate, high and extreme surgical risk. This meta-analysis was performed to assess the safety and efficacy of TAVR compared to surgical aortic valve replacement (SAVR) in intermediate risk patients. We searched PubMed, EMBASE, Web of science, and the Cochrane Central Register of Controlled Trials databases for studies comparing TAVR versus SAVR in patients at intermediate surgical risk, with a mean Society of Thoracic Surgeon score of 3-8% or a mean logistic European risk score of 10-20%. The primary endpoint was to assess the efficacy of TAVR compared to SAVR, defined as all-cause and cardiovascular mortality at 30-days, 1-year, and ≥2 years of follow-up. Secondary endpoints were the safety profile, comprising of cerebrovascular events, myocardial infarctions, permanent pacemaker placement, new onset atrial fibrillation, aortic regurgitation, vascular complications, major bleeding and acute kidney injury. This is the largest and most contemporary meta-analysis of 5647 intermediate risk patients in eleven studies published to date. There were no statistically significant differences in all-cause and cardiac m...Continue Reading

Citations

Oct 2, 2019·European Heart Journal·John G Webb, Uri Landes
May 16, 2020·Current Rheumatology Reports·M ChetritS Kapadia
Oct 11, 2019·Journal of Cardiac Surgery·Callum HowardAmer Harky
Feb 25, 2020·The American Journal of Cardiology·Jeremy Y LevettMark J Eisenberg

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