An updated systematic review and meta-analysis of early outcomes after left atrial appendage occlusion

Journal of Interventional Cardiology
Charan YerasiAshish Pershad

Abstract

Left atrial appendage occlusion (LAAO) is a promising intervention for stroke prevention in patients with non-valvular atrial fibrillation (NVAF). Early outcomes following LAAO have been published in many studies with variable results. This updated meta-analysis aims to provide a summary of the early outcomes of LAAO. Medline/Pubmed, Ovid Journals, Clinical trials, Abstract meetings, Cochrane databases were searched from January 1st, 1999 to November 30th, 2016. This meta-analysis included 49 studies involving 12 415 patients. The median age was 73.5 years (IQR 72-75 years) and 43% were males. Hypertension and diabetes were present in 36% and 15% of the population, respectively. There was a prior history of stroke and congestive heart failure in 14% and 18% of the population, respectively. The median CHADS2 score was 2.9 (IQR 2.6-3.3) and the median HASBLED score was 3.3 (IQR 3-4). LAAO implantation was successful in 96.3% of patients (95.40-97.08, I2  = 76.1%). The pooled proportion of all-cause mortality was 0.28% (0.19-0.38, I2  = 0%). The pooled proportion of all-cause stroke was 0.31% (0.22-0.42, I2  = 9.4%), major bleeding requiring transfusion was 1.71% (1.13-2.41, I2  = 73.2%), and pericardial effusion was 3.25% (2.46-4...Continue Reading

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Citations

Jun 26, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Martin W Bergmann
Jul 19, 2018·Seminars in Cardiothoracic and Vascular Anesthesia·Robert DeeganJeremy M Bennett
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