Abstract
Left atrial appendage occlusion (LAAO) is a promising intervention for stroke prevention in patients with non-valvular atrial fibrillation (NVAF). Early outcomes following LAAO have been published in many studies with variable results. This updated meta-analysis aims to provide a summary of the early outcomes of LAAO. Medline/Pubmed, Ovid Journals, Clinical trials, Abstract meetings, Cochrane databases were searched from January 1st, 1999 to November 30th, 2016. This meta-analysis included 49 studies involving 12 415 patients. The median age was 73.5 years (IQR 72-75 years) and 43% were males. Hypertension and diabetes were present in 36% and 15% of the population, respectively. There was a prior history of stroke and congestive heart failure in 14% and 18% of the population, respectively. The median CHADS2 score was 2.9 (IQR 2.6-3.3) and the median HASBLED score was 3.3 (IQR 3-4). LAAO implantation was successful in 96.3% of patients (95.40-97.08, I2 = 76.1%). The pooled proportion of all-cause mortality was 0.28% (0.19-0.38, I2 = 0%). The pooled proportion of all-cause stroke was 0.31% (0.22-0.42, I2 = 9.4%), major bleeding requiring transfusion was 1.71% (1.13-2.41, I2 = 73.2%), and pericardial effusion was 3.25% (2.46-4...Continue Reading
References
Jun 6, 1992·BMJ : British Medical Journal·P Brennan, A Silman
Feb 1, 1996·The Annals of Thoracic Surgery·J L Blackshear, J A Odell
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 14, 2001·BMJ : British Medical Journal·J A SterneG D Smith
Jul 21, 2001·BMJ : British Medical Journal·J J Deeks
Sep 29, 2001·Journal of Clinical Epidemiology·J A Sterne, M Egger
Nov 1, 2005·Journal of the American College of Cardiology·Albert L WaldoUNKNOWN NABOR Steering Committee
Dec 14, 2005·Statistics in Medicine·Roger M HarbordJonathan A C Sterne
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Nov 28, 2009·Interactive Cardiovascular and Thoracic Surgery·Alan G DawsonJoel Dunning
Jan 6, 2011·Seminars in Neurology·David R Holmes
Mar 10, 2012·Lancet Neurology·Graeme J HankeyUNKNOWN ROCKET AF Steering Committee Investigators
May 11, 2012·Lancet Neurology·J Donald EastonUNKNOWN ARISTOTLE Committees and Investigators
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Dec 19, 2013·Circulation·Sumeet S ChughChristopher J L Murray
Jul 7, 2014·Journal of the American College of Cardiology·David R HolmesVivek Y Reddy
Aug 12, 2014·Journal of the American College of Cardiology·Matthew J PriceMiguel Valderrábano
Nov 17, 2014·JAMA : the Journal of the American Medical Association·Vivek Y ReddyUNKNOWN PROTECT AF Steering Committee and Investigators
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Jun 27, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ulf LandmesserDavid Hildick-Smith
Citations
Jun 26, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Martin W Bergmann
Jul 19, 2018·Seminars in Cardiothoracic and Vascular Anesthesia·Robert DeeganJeremy M Bennett
Oct 13, 2018·Journal of Stroke·Peter D SchellingerMartin Köhrmann
Jun 20, 2019·Echocardiography·Joana Maria RibeiroLino Gonçalves
Sep 3, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael GliksonBernhard Meier
Sep 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael GliksonUNKNOWN ESC Scientific Document Group
Jun 12, 2019·BMC Cardiovascular Disorders·Zhonglin HanWei Xu
Mar 12, 2021·European Heart Journal. Case Reports·Stefano AlbaniPaolo Scacciatella
May 4, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Prabhakar RajiahPraveen Ranganath
Jun 3, 2021·Medicina·Giovanni CimminoPaolo Golino