An updated weight of evidence approach for deriving a health-based guidance value for 4-nonylphenol

Journal of Applied Toxicology : JAT
Xiaomeng LiHuihui Bao

Abstract

4-Nonylphenol (NP) is a persistent estrogen-active compound. Human exposure to NP is primarily through water and food. Although risk assessments of NP have been conducted by the European Union and a few other countries, only the Danish Veterinary and Food Administration, in 2000, proposed a tolerable daily intake of 0.005 mg kg-1 body weight (bw) day-1 . New data have been accumulated since then, prompting an update on the risk assessment of NP. A weight of evidence approach is recommended for use in scientific assessments by several agencies, e.g., European Food Safety Authority, etc. Based on the results of a weight of evidence approach, two methods were used to derive the health-based guidance value (HBGV) for NP in this study, namely a no observed adverse effects level/lowest observable adverse effect level method, and a benchmark dose method. Considering the considerable uncertainty of benchmark dose model fitting of the available data, a tolerable daily intake value of 0.025 mg kg-1 bw day-1 was derived as a provisional HBGV for NP based on the lowest observable adverse effect level value of 15 mg kg-1 bw day-1 of the renal toxicity in rats, together with the uncertainty factor of 600. However, the HBGV of NP still needs ...Continue Reading

References

Nov 1, 1985·Sangyō igaku. Japanese journal of industrial health·H ShimizuH Matsushita
Nov 14, 1997·Regulatory Toxicology and Pharmacology : RTP·H C CunnyJ P Van Miller
Nov 24, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·R E ChapinG Wolfe
May 8, 2001·Archives of Andrology·C de JagerV W Sharp
Jan 10, 2002·Reproductive Toxicology·A HossainiJ J Larsen
Feb 21, 2002·Biological & Pharmaceutical Bulletin·Toshiro NiwaMasanao Katagiri
May 8, 2002·Environmental Science & Technology·Klaus GuentherTorsten Raecker
Oct 26, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tomo DaidojiHiroshi Yokota
Apr 21, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rochelle W TylGlenn S Simon
May 11, 2006·International Archives of Occupational and Environmental Health·A Pilger, H W Rüdiger
Oct 5, 2007·Mutation Research·Sumiko TayamaKuniaki Tayama
Oct 6, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Xu JieLi Yan
Nov 3, 2010·Toxicology and Applied Pharmacology·J Allen DavisQ Jay Zhao
Jun 2, 1998·Environmental Toxicology and Pharmacology·S MüllerC Schlatter
Feb 9, 2012·International Journal of Molecular Sciences·Zhen MaoWei Wang
Apr 3, 2012·Environment International·Irina GyllenhammarMarie Aune
Sep 19, 2012·Environmental and Molecular Mutagenesis·B B GollapudiV Thybaud
Apr 9, 2013·Environmental Pollution·Rong TangXin-Ru Wang
May 18, 2013·The Science of the Total Environment·Ming-Song TsaiMei-Lien Chen
Feb 27, 2014·Environmental Health Perspectives·Jessica A WignallIvan Rusyn
Dec 31, 2014·Environmental Science and Pollution Research International·Alessando CareghiniElena Sezenna
Aug 1, 2015·Biometrics·Holger DetteFrank Bretz
May 28, 2016·Environmental Science and Pollution Research International·Chung-Ching WangSaou-Hsing Liou

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.