An urge to explain the incomprehensible: Geoffrey Harris and the discovery of the neural control of the pituitary gland

Annual Review of Neuroscience
G Raisman

Abstract

Geoffrey Harris is responsible for our view that the brain controls the endocrine system by an exquisitely regulated pattern of synthesis and release of individual members of a family of peptide hormones. These hormones are carried through a portal vascular system that passes from the hypothalamus to the pituitary gland, where they selectively regulate the secretion of the six anterior pituitary hormones. This family of hypothalamic hormones is highly conserved in all vertebrates, including humans. They are essential for all aspects of reproduction--courtship, mating, pregnancy and young rearing--and they are responsible for the seasonal regulation of breeding. The hypothalamic control mechanism for reproduction is sexually dimorphic, with a basic female pattern that becomes masculinized under the influence of specific steroid hormones acting during development. Other members of the hypothalamic hormone family specifically regulate the secretion of pituitary growth hormone and the anterior pituitary hormones controlling the functions of the thyroid and adrenal glands. The secretion of the hypothalamic hormones is itself regulated by the feedback of the target gland hormones (such as estrogen and progesterone), which concurrentl...Continue Reading

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Citations

May 21, 2005·Domestic Animal Endocrinology·C G ScanesL L Anderson
Nov 5, 1999·Clinical and Experimental Pharmacology & Physiology·G Ju
Apr 15, 1999·Annual Review of Neuroscience·E G Jones
Jul 8, 2008·Journal of Neuroendocrinology·H Charlton
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Jul 5, 2015·The Journal of Endocrinology·Geoffrey Raisman
Dec 10, 2016·Nature Reviews. Endocrinology·Paul Le TissierPatrice Mollard
Jun 3, 2009·Nature Reviews. Endocrinology·George P Chrousos
May 16, 2014·Endocrinology·E Ron de Kloet
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Sep 3, 2020·Chaos·Alexander N ChurilovElvira R Salakhova
Feb 16, 2021·Frontiers in Psychiatry·Jennifer A Ross, Elisabeth J Van Bockstaele
May 3, 2000·Medical Hypotheses·F González-Aguilar

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Methods Mentioned

BETA
electron microscopy
X ray

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