Geoffrey Harris is responsible for our view that the brain controls the endocrine system by an exquisitely regulated pattern of synthesis and release of individual members of a family of peptide hormones. These hormones are carried through a portal vascular system that passes from the hypothalamus to the pituitary gland, where they selectively regulate the secretion of the six anterior pituitary hormones. This family of hypothalamic hormones is highly conserved in all vertebrates, including humans. They are essential for all aspects of reproduction--courtship, mating, pregnancy and young rearing--and they are responsible for the seasonal regulation of breeding. The hypothalamic control mechanism for reproduction is sexually dimorphic, with a basic female pattern that becomes masculinized under the influence of specific steroid hormones acting during development. Other members of the hypothalamic hormone family specifically regulate the secretion of pituitary growth hormone and the anterior pituitary hormones controlling the functions of the thyroid and adrenal glands. The secretion of the hypothalamic hormones is itself regulated by the feedback of the target gland hormones (such as estrogen and progesterone), which concurrentl...Continue Reading
The 'suprachiasmatic syndrome': endocrine and behavioural abnormalities following lesions of the suprachiasmatic nuclei in the female rat
Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone
Purification, isolation, and primary structure of the hypothalamic luteinizing hormone-releasing factor of ovine origin. A historical account
Effects of hypothalamic extract and steroids on the secretion of prolactin, growth hormone and luteinizing hormone by the pituitary gland of the terrapin (Chrysemys picta) in vitro
First Geoffrey Harris Memorial lecture. Some recent developments in brain-pituitary-ovarian physiology
Hypothalamic release of atrial natriuretic factor and beta-endorphin into rat hypophysial portal plasma: relationship to oestrous cycle and effects of hypophysectomy
Corticotrophin-releasing factor-41, vasopressin and oxytocin release into hypophysial portal blood in the rat: effects of electrical stimulation of the hypothalamus, amygdala and hippocampus
Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome
Sexual dimorphism in the neuropil of the preoptic area of the rat and its dependence on neonatal androgen
Hormonal differentiation of the developing central nervous system with respect to patterns of endocrine function
Localization of neurophysin-II in the hypothalamo-neurohypophysial system of the pig by immunofluorescence histochemistry
Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones
Discovery of modification of the synthetic tripeptide-sequence of the thyrotropin releasing hormone having activity
Prolactin turnover in rat adenohypophyses in vivo: its evaluation as a method for estimating secretion rates
The luteinizing hormone releasing activity of extracts of blood from the hypophysial portal vessels of rats
Luteinizing hormone releasing factor in rat hypophysial portal blood collected during electrical stimulation of the hypothalamus
Blood samples from the pituitary stalk of the rat: method of collection and factors determining volume
Therapeutic potential of the LHRH agonist, ICI 118630, in the treatment of advanced prostatic carcinoma
Therapeutic use of pituitary desensitization with a long-acting lhrh agonist: a potential new treatment for idiopathic precocious puberty
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Structure and function in the conceptual development of mammalian neuroendocrinology between 1920 and 1965
60 YEARS OF NEUROENDOCRINOLOGY: MEMOIR: working in the 'Huts' with the professor: the first Maudsley years
60 YEARS OF NEUROENDOCRINOLOGY: The posterior pituitary, from Geoffrey Harris to our present understanding
Immune neuroendocrine phenotypes in Coturnix coturnix: do avian species show LEWIS/FISCHER-like profiles?
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives.
Amygdala and Midbrain Dopamine
The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.
Amygdala: Sensory Processes
Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.
Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.