An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation

Movement Disorders : Official Journal of the Movement Disorder Society
Eng-King TanRatnagopal Pavanni

Abstract

We report on the cause and effect relationship of restless legs syndrome (RLS) with L-thyroxine treatment in a hypothyroid patient with low serum ferritin. Upon challenge and withdrawal of L-thyroxine, there was a significant change in the International Restless Legs Syndrome Study Group severity score (26/40 to 6/40), the periodic limb movements (PMLS) index (20/hour to 10/hour), the number of arousals due to PLMS (59 to 22), sleep efficiency (74 to 85%), and biochemical parameters. RLS symptoms can complicate thyroxine replacement in at-risk hypothyroid patients with low serum ferritin. Early diagnosis and iron replacement could significantly reduce patient morbidity.

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Citations

Dec 21, 2004·International Journal of Clinical Practice·E K TanY L Lo
Dec 6, 2012·Translational Neurodegeneration·Tasneem Peeraully, Eng-King Tan
May 20, 2015·Expert Opinion on Drug Safety·Dénes ZádoriLászló Vécsei
Apr 18, 2015·Nephro-urology Monthly·Farzaneh ChavoshiNeda Izadianmehr
Feb 28, 2018·The Annals of Pharmacotherapy·Edna Patatanian, Melanie K Claborn
Jun 4, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·T M OstroumovaV A Parfenov
Jul 9, 2005·Current Opinion in Neurology·Birgit Högl, Werner Poewe
May 13, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Marcello MocciaPaolo Barone

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