Anabolic actions of PTH in murine models: two decades of insights.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Laura E ZweiflerLaurie K McCauley

Abstract

Parathyroid hormone (PTH) is produced by the parathyroid glands in response to low serum calcium concentrations where it targets bones, kidneys, and indirectly, intestines. The N-terminus of PTH has been investigated for decades for its ability to stimulate bone formation when administered intermittently (iPTH) and is used clinically as an effective anabolic agent for the treatment of osteoporosis. Despite great interest in iPTH and its clinical use, the mechanisms of PTH action remain complicated and not fully defined. More than 70 gene targets in more than 90 murine models have been utilized to better understand PTH anabolic actions. Because murine studies utilized wild-type mice as positive controls, a variety of variables were analyzed to better understand the optimal conditions under which iPTH functions. The greatest responses to iPTH were in male mice, with treatment starting later than 12 weeks of age, a treatment duration lasting 5-6 weeks, and a PTH dose of 30-60 μg/kg/day. This comprehensive study also evaluated these genetic models relative to the bone formative actions with a primary focus on the trabecular compartment revealing trends in critical genes and gene families relevant for PTH anabolic actions. The summa...Continue Reading

References

Jan 1, 1981·Calcified Tissue International·G A Rodan, T J Martin
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S L FerrariL J Suva
Feb 22, 2002·Journal of Cellular Physiology·Pierre J Marie
Sep 20, 2002·Endocrinology·Burak DemiralpLaurie K McCauley
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Liming WangRobert F Spurney
Oct 12, 2004·Gene·Jennifer J WestendorfTania M Schroeder
Nov 19, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Clifford J RosenMark C Horowitz
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yingben XueDengshun Miao
Feb 4, 2006·Biochemical and Biophysical Research Communications·M M HurleyJ D Coffin
Dec 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Urszula T IwaniecRobert Brommage
Dec 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Junro YamashitaLaurie K McCauley
Jan 1, 2008·The Journal of Biological Chemistry·Liza J RaggattNicola C Partridge
Feb 19, 2008·The Journal of Biological Chemistry·Huafeng ZhangGregg L Semenza
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rana SamadfamDavid Goltzman
May 10, 2008·Endocrinology·Tsutomu KawanoKarl Insogna
May 29, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S HuangYin Tintut
Feb 4, 2009·Journal of Cellular Physiology·Alexander G RoblingJoseph P Bidwell
Mar 3, 2009·Cellular Signalling·Nabanita S Datta, Abdul B Abou-Samra
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei YaoNancy E Lane
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ina KramerMichaela Kneissel
Sep 3, 2009·Cell Metabolism·Masakazu TerauchiRoberto Pacifici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scandinavian Journal of Clinical and Laboratory Investigation
Derya AslanNiklas Rye Jørgensen
Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Takatoshi KakutaMasafumi Fukagawa
Clinics in Geriatric Medicine
Mishaela R Rubin, John P Bilezikian
© 2021 Meta ULC. All rights reserved