Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats

Pharmaceutical Biology
M T Yakubu, Anthony Jide Afolayan

Abstract

Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. Sixty male rats were grouped into four (A-D) consisting of 15 each. Group A (control) was orally treated with 0.5 mL of distilled water for 14 days while groups B, C and D were treated like the control except they received 0.5 mL containing 25, 50, and 100 mg/kg body weight of the extract respectively. All the doses of the extract increased (P <0.05) the testicular-body weight ratio as well as alkaline phosphatase activity, glycogen, sialic acid, protein, and cholesterol content of the testes except the single administration of 100 mg/kg body weight which compared well (P>0.05) with the controls for glycogen and cholesterol. The testicular and serum testosterone concentration were increased except in the 100 mg/kg body weight where the effect on the tissue and serum hormone did not manifest until after the first and seven daily doses respectively. Testicular acid phosphatase activity, serum follicle stimulating and luteinizing hormone concentrations also increased at all the doses except in the 100 mg/kg body weight where the effect on the enzyme and the h...Continue Reading

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Citations

Jan 15, 2017·BMC Complementary and Alternative Medicine·Pierre WatchoAlbert Kamanyi
Dec 16, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Islam HusainShabana I Khan
Jun 4, 2020·Journal of Ethnopharmacology·Olusola Bodede, Gerhard Prinsloo
Aug 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelisiwe Prenate MasukuSogolo Lucky Lebelo
Jul 10, 2019·Journal of Natural Products·Ji-Yeong BaeIkhlas A Khan

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