Anabolic, doping, and lifestyle drugs, and selected metabolites in wastewater--detection, quantification, and behaviour monitored by high-resolution MS and MS(n) before and after sewage treatment

Analytical and Bioanalytical Chemistry
Horst Fr SchröderMario Thevis

Abstract

Municipal wastewater has been examined for steroids, beta(2)-agonists, stimulants, diuretics, and phosphodiesterase type V inhibitors (PDE type V inhibitors), which are "dual-use-drugs" applied either as anabolic, doping, and lifestyle drugs or for treatment of diverse diseases. To identify their origin, fitness centre discharges under suspicion of being point sources and sewage-treatment plant feed and effluents were sampled and concentrations determined. Sensitive and selective methods for determination and quantification based on solid-phase extraction (SPE) followed by high-performance liquid chromatography-high resolution mass and tandem mass spectrometry (HPLC-(HR)MS and HPLC-MS-MS) were developed and established for analysis of these compounds in wastewater and to assess their effect on the environment. The methods developed enabled quantification at trace concentrations (limit of quantification (LOQ): 5 ng L(-1)). Of the steroids and stimulants under investigation, testosterone, methyltestosterone, and boldenone or ephedrine, amphetamine, and MDMA (3,4-methylendioxy-N-methylamphetamine) were observed at up to 5 microg L(-1) (ephedrine). Of the beta(2)-agonists salbutamol only, and of the diuretics furosemide and hydroch...Continue Reading

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Citations

Mar 3, 2012·Environmental Science and Pollution Research International·Cristian Gómez-CanelaJosep Caixach
Dec 19, 2013·Environmental Science & Technology·Daniel A BurgardJennifer A Field
Jul 10, 2012·Journal of Hazardous Materials·Nuno RatolaAthanasios Katsoyiannis
Jul 4, 2013·The Science of the Total Environment·Fabio TemussiMarina Isidori
Aug 30, 2014·Sports Medicine·Olivier de HonMaarten van Bottenburg
May 21, 2013·Physiology & Behavior·Borna PayandemehrAhmad Reza Dehpour
Jan 18, 2018·Analytical and Bioanalytical Chemistry·Ana CausanillesPim de Voogt
Mar 23, 2019·Drug Testing and Analysis·Katja M ShimkoKevin V Thomas
Jun 2, 2017·Environmental Science and Pollution Research International·Heli Sirén, Samira El Fellah
Jul 1, 2020·PLoS Computational Biology·Ethan D EvansEric J Alm
Nov 22, 2020·Environmental Science and Pollution Research International·Mariana Guadalupe AbrileMaría Eugenia Lovato
Jan 5, 2021·Environmental Science and Pollution Research International·Si-Yu LiuDe-Gao Wang
Dec 15, 2010·Environmental Science & Technology·Athanasios Katsoyiannis, Kevin C Jones
Dec 8, 2011·Analytical Chemistry·Susan D Richardson
Apr 19, 2011·Analytical Chemistry·Ana Ballesteros-Gómez, Soledad Rubio

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