PMID: 9546622Apr 18, 1998Paper

Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: the genistein effect is enhanced by zinc

Molecular and Cellular Biochemistry
M Yamaguchi, Y H Gao

Abstract

The effect of genistein and genistin on bone components in the femoral-metaphyseal tissues obtained from elderly female rats was investigated in vitro. The metaphyseal tissues were cultured for 24 h in a medium containing either vehicle, genistein (10(-8)-10(-5) M) or genistin (10(-7)-10(-5) M). The presence of genistein or genistin caused a significant increase in alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in the metaphyseal tissues. The effect of genistein was greater than that of genistin. The bone components increased by genistein (10(-5) M) or genistin (10(-5) M) were completely blocked by the presence of cycloheximide (10(-6) M). The presence of zinc sulfate (10(-5) M) caused a significant increase in the genistein (10(-5) M)-elevated alkaline phosphatase activity, DNA and calcium contents. The enhancement with zinc was not seen by genistin (10(-5) M). The stimulatory effect of zinc on the genistein-induced increase in bone components of the metaphyseal tissues was completely blocked by the presence of cycloheximide (10(-6) M). The present results suggest that genistein and genistin have an anabolic effect on bone metabolism in the femoral-metaphyseal tissues of elderly rats, and that ...Continue Reading

Citations

Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nunziata MorabitoFrancesco Squadrito
Nov 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masayoshi Yamaguchi
Aug 10, 2007·Phytotherapy Research : PTR·Jong-Geun JeongSeong Hwan Kim
Apr 6, 2012·Molecular and Cellular Biochemistry·Masayoshi Yamaguchi
May 3, 2011·Molecular and Cellular Biochemistry·Masayoshi Yamaguchi, M Neale Weitzmann
Mar 17, 2004·The Proceedings of the Nutrition Society·Francesco Branca
Feb 5, 2000·Biochemical Pharmacology·E Sugimoto, M Yamaguchi

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