PMID: 15374126Mar 1, 1997Paper

Anabolic effects of estrogen and parathyroid hormone on skeletal tissues: the use of creatine kinase B activity as a response marker

Archives of Gerontology and Geriatrics
Alvin M KayeDalia Somjen

Abstract

The rapid stimulation of the specific activity of the brain type isozyme of creatine kinase (CK BB) is an almost universal marker of cell stimulation. We have studied its stimulation in skeletal-derived cells and shown that the increase in its activity is closely correlated with the biochemical parameter of cell proliferation - [(3)thymidine incorporation into DNA - and with the morphological parameters of bone growth, increase in thickness of cortical bone and of the number of cells in the proliferating zone of the epiphyseal growth plate. We have used the increase in CK activity to demonstrate sex specific stimulation of diaphyseal bone, exclusively by estrogens in females and by androgens in males, and the dependence of sex steroid stimulation on an adequate level of vitamin D. After finding that parathyroid hormone can act as a mitogen via a phospholipase-C-phosphoinositide turnover pathway, we collaborated with colleagues at the GBF in Braunschweig to find that mid-region fragments of PTH could act exclusively as mitogens, without stimulating cAMP production leading to bone resorption. hPTH (28-48) variants designed to be resistant to proteolysis were efficient in stimulating CK specific activity in vitro and in vivo and i...Continue Reading

References

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Citations

Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Dalia Somjen, Israel Yoles
Nov 6, 2010·Journal of Cellular Biochemistry·V RouachD Somjen
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·G A SilvaR L Reis

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