PMID: 16515768Mar 7, 2006Paper

Anabolic therapy for osteoporosis: parathyroid hormone

Current Rheumatology Reports
Felicia Cosman

Abstract

Recombinant human parathyroid hormone (PTH 1-34) is the only anabolic agent currently approved for the treatment of osteoporosis. The term anabolic is based on mechanism of action. PTH stimulates bone formation, in contrast to antiresorptive agents, which reduce bone resorption and formation. Recent investigations involving the PTH(1-34) and PTH(1-84) peptides, alone and in combination or sequential regimens with antiresorptive agents, have provided a greater understanding of the place of PTH in the armamentarium against osteoporosis. These studies indicate that adding a bisphosphonate to PTH in previously untreated individuals does not produce additional bone benefit; however, sequential use of PTH followed-up by an antiresorptive agent is highly effective at increasing bone mineral density. Adding PTH after an antiresorptive agent also produces substantial bone density increments, though the magnitude of bone density increase may differ for different antiresorptive agents. PTH can repair underlying micro-architectural defects in bone, improve bone mass substantially, and perhaps change macro-architecture and geometry of bone. There are still many unanswered questions regarding PTH treatment of osteoporosis, including the opti...Continue Reading

References

Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F CosmanR Lindsay
Oct 3, 1998·JAMA : the Journal of the American Medical Association·J S FinkelsteinR M Neer
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N E LaneC D Arnaud
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F CosmanR Lindsay
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D W DempsterR Lindsay
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Michael Parfitt
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S OrwollG A Gaich
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert MarcusBruce Mitlak
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Q RehmanN E Lane
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R ZanchettaS L Myers
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Sep 23, 2003·The New England Journal of Medicine·Joel S FinkelsteinRobert M Neer
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Anthony B HodsmanRobert Lindsay
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yebin JiangErik F Eriksen
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bruce EttingerImre Pavo
Jun 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Etah S KurlandJohn P Bilezikian
Aug 24, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-M KaufmanB H Mitlak
Apr 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Harald DobnigErik F Eriksen
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peiqi ChenRachel B Wagman
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Monique ArlotErik Fink Eriksen
Aug 10, 2005·Archives of Internal Medicine·Michael R McClungErik F Eriksen
Aug 12, 2005·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Aug 12, 2005·The New England Journal of Medicine·Felicia CosmanRobert Lindsay

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Citations

Jan 28, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S BharadwajA S Naidu
May 18, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Satish BharadwajA Satyanarayan Naidu
May 29, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara M Obermayer-PietschUNKNOWN EUROFORS Investigators
Nov 10, 2010·Expert Opinion on Biological Therapy·Qin ShiJulio C Fernandes
Jul 22, 2011·Expert Review of Endocrinology & Metabolism·Mengqian ChenRalph Buttyan
Apr 1, 2009·Therapeutic Advances in Musculoskeletal Disease·Lisa-Ann Fraser, Jonathan D Adachi
Jul 16, 2010·Expert Opinion on Biological Therapy·Harald J J Verhaar, Willem F Lems

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