PMID: 19128766Jan 9, 2009Paper

Anaemia and neutropenia in a cohort of non-infected children of HIV-positive mothers

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
M Fernández IbietaJ Regidor

Abstract

Mother-to-child HIV transmission is currently around 1% in western countries, due to prevention measures. Antiretroviral drugs do have adverse effects, anaemia and myelosupression caused by AZT being the most observed effects. In the present study, we analyse the prevalence of anaemia and neutropenia in an uninfected children cohort born to HIV-infected women. We followed up 623 uninfected children belonging to the FIPSE cohort according to standardised protocols. This cohort groups 8 hospitals from Madrid and follows up HIV infected pregnant women and their children. Anaemia and neutropenia were defined according to the ACTG (AIDS Clinical Trails Group) toxicity tables. Children were classified according to prematurity, ethnic origin, birth weight, withdrawal syndrome, in-utero treatment and neonatal prophylaxis. Categorical variables were compared with the chi2 or the Fisher tests. Anaemia was observed in 188 (30.1%) children during follow-up and 161 (25.8%) had anaemia grade 2 or higher. Prematurity (p < 0.001), low birth weight (p = 0.005) and Highly Active Antiretroviral Treatment (HAART) with Protease Inhibitors (p = 0.016) were associated with higher percentages of anaemia in children. Nadir haemoglobin values were reach...Continue Reading

Citations

Jan 27, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Scott Dryden-PetersonShahin Lockman
Jan 21, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cinta MoraledaDenise Naniche

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