Anaemia in patients with HIV-associated TB: relative contributions of anaemia of chronic disease and iron deficiency

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
Andrew D KerkhoffStephen D Lawn

Abstract

Anaemia commonly complicates both human immunodeficiency virus (HIV) infection and tuberculosis (TB), contributing substantially to morbidity and mortality. The mechanisms underlying anaemia and corresponding treatments in co-infected patients are poorly defined. To determine the relative contributions of anaemia of chronic disease (ACD) and iron deficiency to anaemia in patients with HIV-associated TB. Consecutively recruited hospitalised (n = 102) and matched ambulatory patients (n = 51) with microbiologically confirmed HIV-associated TB in Cape Town, South Africa, were included. Haemoglobin levels, iron status markers, hepcidin and pro-inflammatory cytokines in blood were measured. We determined the prevalence of ACD and iron-deficiency anaemia (IDA) using seven different published definitions of IDA. More than 80% of enrolled HIV-associated TB patients were anaemic, and anaemia was more severe among in-patients. Over 95% of anaemic HIV-associated TB patients had ACD, whereas the proportion with IDA using a range of seven different definitions was low overall (median <3%, range 0-32.6) in both patient groups. The proportion with IDA and hepcidin concentration ⩿ 20.0 ng/ml (predictive of responsiveness to oral iron supplement...Continue Reading

Citations

Mar 29, 2018·BMC Public Health·Rubeshan PerumalNesri Padayatchi
Dec 21, 2017·Journal of Translational Medicine·Eugenia Quiros-RoldanIsabella Zanella
Apr 23, 2019·Annals of the New York Academy of Sciences·Camila M Chaparro, Parminder S Suchdev
Jun 8, 2018·The Journal of Nutrition·Sean LynchDaniel J Raiten
May 10, 2020·Advances in Nutrition·Ajibola I AbioyeWafaie W Fawzi
May 24, 2018·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Marcia Danielle FerreiraMarcelo Cordeiro-Santos
Feb 3, 2021·PloS One·Edson Beyker de MendonçaValeria Cavalcanti Rolla

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Methods Mentioned

BETA
ELISA

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Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

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