Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia.

Basic Research in Cardiology
Patricia WischmannMalte Kelm

Abstract

Anaemia is frequently present in patients with acute myocardial infarction (AMI) and contributes to an adverse prognosis. We hypothesised that, besides reduced oxygen carrying capacity, anaemia is associated with (1) red blood cell (RBC) dysfunction and a reduced circulating nitric oxide (NO) pool, (2) compensatory enhancement of vascular and cardiac endothelial nitric oxide synthase (eNOS) activity, and (3) contribution of both, RBC dysfunction and reduced circulatory NO pool to left ventricular (LV) dysfunction and fatal outcome in AMI. In mouse models of subacute and chronic anaemia from repeated mild blood loss the circulating NO pool, RBC, cardiac and vascular function were analysed at baseline and in reperfused AMI. In anaemia, RBC function resulted in profound changes in membrane properties, enhanced turnover, haemolysis, dysregulation of intra-erythrocytotic redox state, and RBC-eNOS. RBC from anaemic mice and from anaemic patients with acute coronary syndrome impaired the recovery of contractile function of isolated mouse hearts following ischaemia/reperfusion. In anaemia, the circulating NO pool was reduced. The cardiac and vascular adaptation to anaemia was characterised by increased arterial eNOS expression and acti...Continue Reading

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Citations

Apr 1, 2021·Free Radical Biology & Medicine·Ali MahdiJohn Pernow
Apr 28, 2021·BMC Cardiovascular Disorders·Ashwin RadhakrishnanJonathan N Townend
Aug 10, 2021·JACC. Basic to Translational Science·Javier InserteIgnacio Ferreira-González

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Methods Mentioned

BETA
flow cytometry
ELISA
Assay
NMR
rheology

Software Mentioned

iox
GraphPad Prism
SPSS
FlowJo TreeStar
Power
LabVIEW
Image Studio Lite
ParaVision
Graphpad

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