Anaemia treatment in chronically dialysed children: a multicentre nationwide observational study

Scandinavian Journal of Urology and Nephrology
Anna JanderMarcin Tkaczyk

Abstract

Erythropoiesis-stimulating agents (ESAs) are applied as a standard therapy in children with anaemia in chronic kidney disease. The aim of this study was to describe the efficacy and details of ESA treatment in a population of dialysed children in Poland. The study had a prospective observational design and was performed in 12 dialysis centres. The study group comprised 117 dialysed children with a mean age at enrolment of 165.33 (97.18-196.45) months. Dialysed children were treated mostly with epoietin beta and darbepoietin. The mean dose of ESA was 99 (68-147) U/kg/week with a significant difference between patients on peritoneal dialysis [83 (54-115)] and haemodialysis [134 (103-186)] (p < 0.0001). The mean haemoglobin of all the time-point tests during 6 months was 10.91 ± 1.18 g/dl. The efficacy of anaemia treatment was unsatisfactory in 52% of subjects. In multivariate analysis, initial haemoglobin level <10 g/l, any infection, younger age at first dialysis, malnutrition and inadequate ESA dosage remained significant predictors of anaemia. The study revealed that anaemia treatment in Polish children is unsatisfactory. Late commencement of the treatment, inadequate dosing, malnutrition and infections could constitute risk f...Continue Reading

References

Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T B Drüeke
Jun 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R Van Damme-LombaertsH Stocker
May 9, 2001·The Journal of Pediatrics·W SeeherunvongG Zilleruelo
May 17, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cornelis H Schröder, UNKNOWN European Pediatric Peritoneal Dialysis Working Group
Jul 29, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bradley A Warady, Martin Ho
Dec 17, 2003·Kidney International·Blanche M ChaversWendy L St Peter
Sep 1, 2006·Journal of the American Society of Nephrology : JASN·Sandra AmaralSusan Furth
Jan 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan M Koshy, Denis F Geary
Mar 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael BoehmChristoph Aufricht
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI
Dec 6, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Malcolm LewisUNKNOWN BAPN
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Franz Schaefer
Aug 13, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ruediger E Port, Otto Mehls
Sep 19, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Oluwatoyin Fatai BamgbolaMaria Coco
Dec 6, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Amy O StaplesLarry A Greenbaum
May 14, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Meredith A AtkinsonAlicia M Neu

❮ Previous
Next ❯

Citations

Sep 23, 2014·Jornal de pediatria·Johnathan S de FreitasAlessandra V Naghettini
Jun 21, 2020·Nutrients·Michał WicińskiBartosz Malinowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Karlijn J van StralenESPN/ERA-EDTA Registry
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Ruediger E Port, Otto Mehls
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Sai Ram Keithi-Reddy, Ajay K Singh
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Meredith A AtkinsonSusan L Furth
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Meredith A AtkinsonDiane Frankenfield
© 2021 Meta ULC. All rights reserved