Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
John S TanakaMatthew S Kelly

Abstract

Certain anaerobic bacteria are important for maintenance of gut barrier integrity and immune tolerance and may influence the risk of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a single-center retrospective cohort study of allogeneic HSCT recipients to evaluate associations between receipt of antibiotics with an anaerobic spectrum of activity and GVHD outcomes. We identified 1214 children and adults who developed febrile neutropenia between 7 days before and 28 days after HSCT and compared GVHD risk and mortality among patients who received anaerobic antibiotics (piperacillin-tazobactam or carbapenems; n = 491) to patients who received only antibiotics with minimal activity against anaerobes (aztreonam, cefepime, or ceftazidime; n = 723). We performed metagenomic sequencing of serial fecal samples from 36 pediatric patients to compare the effects of specific antibiotics on the gut metagenome. Receipt of anaerobic antibiotics was associated with higher hazards of acute gut/liver GVHD (hazard ratio [HR], 1.26; 95% confidence interval [CI], 1.03 to 1.54) and acute GVHD mortality (HR, 1.63; 95% CI, 1.08 to 2.46), but not chronic GVHD diagnosis (HR, 1.04; 95% CI: .84...Continue Reading

References

Nov 1, 1993·The Journal of Antimicrobial Chemotherapy·J DuvalC Rollin
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·H M HamerR-J Brummer
Mar 23, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·John M MagenauSophie Paczesny
Jan 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of America
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
May 2, 2012·The Journal of Experimental Medicine·Robert R JenqMarcel R M van den Brink
Jun 22, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying TaurEric G Pamer
Aug 28, 2013·Current Opinion in Pharmacology·Vadivel GanapathyNagendra Singh
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Dec 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Madan H JagasiaMary E D Flowers
Mar 31, 2015·International Journal of Hematology·Hideki NakasoneDavid B Miklos
May 16, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert R JenqMarcel R M van den Brink
Sep 30, 2015·Nature Methods·Duy Tin TruongNicola Segata
Dec 20, 2015·PLoS Computational Biology·James KaminskiCurtis Huttenhower
Feb 14, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tiffany R Simms-WaldripAndrew Y Koh
Feb 25, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniela WeberErnst Holler
Jul 29, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lindsey E Romick-RosendaleStella M Davies
Apr 20, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vi P DoanSairah Ahmed
May 9, 2019·Open Forum Infectious Diseases·Jessica R Galloway-PeñaPablo C Okhuysen
Jun 14, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sung-Eun LeeChang-Ki Min

❮ Previous
Next ❯

Citations

Dec 10, 2020·Experimental Hematology & Oncology·Jifeng YuZhongxing Jiang
Nov 14, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Sho OguraHideki Araoka
Apr 26, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jose F CamargoDenise Pereira
Jun 10, 2021·Transplantation and Cellular Therapy·Sarah A HolsteinPhilip L McCarthy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.