Anaerobic biotransformation of estrogens

The Science of the Total Environment
Cynthia P Czajka, Kathleen L Londry

Abstract

Estrogens are important environmental contaminants that disrupt endocrine systems and feminize male fish. We investigated the potential for anaerobic biodegradation of the estrogens 17-alpha-ethynylestradiol (EE2) and 17-beta-estradiol (E2) in order to understand their fate in aquatic and terrestrial environments. Cultures were established using lake water and sediment under methanogenic, sulfate-, iron-, and nitrate-reducing conditions. Anaerobic degradation of EE2 (added at 5 mg/L) was not observed in multiple trials over long incubation periods (over three years). E2 (added at 5 mg/L) was transformed to estrone (E1) under all four anaerobic conditions (99-176 microg L-1 day-1), but the extent of conversion was different for each electron acceptor. The oxidation of E2 to E1 was not inhibited by E1. Under some conditions, reversible inter-conversion of E2 and E1 was observed, and the final steady state concentration of E2 depended on the electron-accepting condition but was independent of the total amount of estrogens added. In addition, racemization occurred and E1 was also transformed to 17-alpha-estradiol under all but nitrate-reducing conditions. Although E2 could be readily transformed to E1 and in many cases 17-alpha-est...Continue Reading

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Citations

Aug 27, 2013·Environmental Science and Pollution Research International·V Gabet-GiraudM Coquery
Jun 18, 2014·Journal of Hazardous Materials·Shubhajit SarkarMadhumita B Ray
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