PMID: 9435058Jan 22, 1998Paper

Anaerobic killing of oral streptococci by reduced, transition metal cations

Applied and Environmental Microbiology
J C DunningR E Marquis

Abstract

Reduced, transition metal cations commonly enhance oxidative damage to cells caused by hydroperoxides formed as a result of oxygen metabolism or added externally. As expected, the cations Fe2+ and Cu+ enhanced killing of Streptococcus mutans GS-5 by hydroperoxides. However, unexpectedly, they also induced lethal damage under fully anaerobic conditions in a glove box with no exposure to O2 or hydroperoxides from initial treatment with the cations. Sensitivities to anaerobic killing by Fe2+ varied among the organisms tested. The oral streptococci Streptococcus gordonii ATCC 10558, Streptococcus rattus FA-1, and Streptococcus sanguis NCTC 10904 were approximately as sensitive as S. mutans GS-5. Enterococcus hirae ATCC 9790, Actinomyces viscosus OMZ105E, and Actinomyces naeslundii WVU45 had intermediate sensitivity, while Lactobacillus casei ATCC 4646 and Escherichia coli B were insensitive. Killing of S. mutans GS-5 in response to millimolar levels of added Fe2+ occurred over a wide range of temperatures and pH. The organism was able to take up ferrous iron, but ferric reductase activity could not be detected. Chelators, uric acid, and thiocyanate were not effective inhibitors of the lethal damage. Sulfhydryl compounds, ferricyani...Continue Reading

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Citations

Dec 31, 2014·Journal of Animal Science·Y L MaM Vazquez-Añón
Jul 8, 2015·Applied and Environmental Microbiology·Salima MathewsMarc Solioz
Jan 24, 2016·Applied and Environmental Microbiology·Xi Jia Ooi, Kai Soo Tan
Oct 25, 2016·Molecular Oral Microbiology·J L BakerR G Quivey
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WeissmanD Kornitzer
Apr 5, 2005·Journal of Bacteriology·Roberta C FaustoferriRobert G Quivey
Apr 9, 2013·Applied and Environmental Microbiology·Lina J BirdDianne K Newman
May 3, 2000·Journal of Applied Microbiology·M ElliL Morelli
Sep 1, 2009·Applied and Environmental Microbiology·Alexandre J Poulain, Dianne K Newman
Dec 13, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Danijela KrstićVesna Vasić
Dec 15, 2010·Applied and Environmental Microbiology·Christophe Espírito SantoGregor Grass
Jul 14, 2012·Brazilian Oral Research·Cecília Cláudia Costa RibeiroJaime Aparecido Cury
Sep 6, 2015·Applied and Environmental Microbiology·Brittany D BennettJeffrey A Gralnick
Feb 1, 2007·Journal of Applied Oral Science : Revista FOB·Melissa Thiemi KatoMarília Afonso Rabelo Buzalaf
Jan 31, 2018·Journal of Bacteriology·Brittany D BennettJeffrey A Gralnick
Jun 20, 2018·Applied and Environmental Microbiology·Casey BryceAndreas Kappler
Jun 30, 2019·Free Radical Biology & Medicine·B D Bennett, J A Gralnick
Oct 29, 2000·Cell·M M WöstenE A Groisman
Jun 20, 2006·Archives of Oral Biology·Marília Afonso Rabelo BuzalafAna Carolina Magalhães
May 11, 2011·Archives of Oral Biology·Karina Mirela Ribeiro Pinto AlvesAlberto Carlos Botazzo Delbem

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