Anaesthesia and the kidney

Anaesthesia and Intensive Care
M J CousinsJ L Plummer


Applied anatomy and physiology of the kidney are briefly reviewed. This includes an account of renal blood flow, glomerular filtration rate, juxtaglomerular apparatus, renal autoregulation and intra-renal blood flow distribution, tubular transport mechanisms, solute handling in proximal tubule, function of loop of Henle and distal tubule system. This section concludes with a summary of changes in tubule fluid along the length of the nephron. Acute effects of anaesthesia are reviewed in detail. Indirect effects include those on circulatory and sympathetic nervous systems, autoregulation, endocrine systems such as those involving anti-diuretic hormone, adrenaline and noradrenaline, renin-angiotensin and aldosterone. Direct effects of anaesthesia on renal function have now been confirmed both in vitro and in vivo. Delayed direct nephrotoxicity of anaesthetics relates predominantly to methoxyflurane (MOF) and its metabolism to inorganic fluoride. Other factors are MOF dose, genetics, age, enzyme induction, obesity, other nephrotoxic drugs. Clinical implications are presented. Enflurane nephrotoxicity is rare but aetiologic factors are similar to the foregoing. Isoflurane and halothane are not nephrotoxic. A consideration of the inf...Continue Reading


Aug 1, 1977·Anesthesiology·R I Mazze
Nov 9, 1979·Science·F A SchanneJ L Farber
Mar 1, 1979·Anesthesiology·J R DooleyJ D Borel
Nov 1, 1978·Anaesthesia and Intensive Care·M J CousinsR Whitehead
Apr 1, 1975·Anesthesiology·L R GreensteinR I Mazze
Sep 1, 1975·Anesthesiology·D A HoladayM A Zumbiel
Jan 1, 1976·Anesthesiology·M J CousinsR I Mazze
May 1, 1976·Anesthesiology·N YoshimuraV Fiserova-Bergerova
May 1, 1973·Anesthesiology·H F Cascorbi, A V Singh-Amaranath
Mar 1, 1972·British Journal of Anaesthesia·K B Slawson
Jul 10, 1969·The New England Journal of Medicine·L E Earley, T M Daugharty
Mar 1, 1972·British Journal of Anaesthesia·J C Atherton
Aug 1, 1973·Anaesthesia and Intensive Care·M J Cousins, R I Mazze
Oct 1, 1974·Annals of Internal Medicine·M N HartnettW M Bennett
Jan 1, 1973·Canadian Anaesthetists' Society Journal·R I Mazze, M J Cousins
Feb 1, 1974·Anesthesiology·R W Loehning, R I Mazze
Apr 1, 1973·British Journal of Anaesthesia·G A BarrJ C Kosek
Apr 1, 1973·British Journal of Anaesthesia·R I Mazze, M J Cousins
Jan 1, 1974·The American Journal of Physiology·F R KahlJ P Szidon
Jan 1, 1974·Anesthesiology·B A HittJ R Trudell
Jun 1, 1974·Anesthesiology·R I MazzeG A Barr
Aug 1, 1974·The American Journal of Physiology·R D Bastron, G J Kaloyanides
Jul 1, 1967·Physiological Reviews·A J Vander
Apr 20, 1972·The New England Journal of Medicine·N K HollenbergJ P MERRILL
Sep 1, 1971·Anesthesiology·R E ChaseF E Mack
Dec 11, 1971·British Medical Journal·E A Proctor, F L Barton
May 1, 1967·The American Journal of Medicine·F C Bartter, W B Schwartz
Jul 1, 1967·The Journal of Clinical Investigation·S M RosenJ P MERRILL
Sep 24, 1970·The New England Journal of Medicine·J A FrascinoP P Rosen
Mar 15, 1971·Experientia·D F Dedrick, N M Greene
Jul 1, 1968·Diseases of the Chest·J C Norman
Jun 1, 1968·British Journal of Anaesthesia·E JacobsenM Lunding
Sep 1, 1966·Anesthesiology·L D VANDAM
Sep 1, 1966·Anesthesiology·W B CrandellA Macdonald
Nov 1, 1966·Anesthesiology·S DeutschW H Wu
Jan 1, 1966·Acta Anaesthesiologica Scandinavica. Supplementum·H M Gorman, N W Craythorne
Aug 1, 1967·Annals of Surgery·F D Moore, G Shires
Mar 27, 1982·Lancet·D Bichet, R W Schrier
Jul 1, 1982·Anesthesiology·R I MazzeM E Heerdt
Oct 20, 1980·Life Sciences·M S Miller, A J Gandolfi
Jan 1, 1953·Acta Pharmacologica Et Toxicologica·O ERANKOM E PITKANEN
Feb 1, 1955·The American Journal of Medicine·P E TESCHANB F Rush
Nov 1, 1955·Anesthesiology·L BACHMAN
Feb 28, 1956·The Journal of Physiology·J D ROBERTSOND WHITTERIDGE
May 1, 1961·Progress in Cardiovascular Diseases·B OCHWADT
Aug 1, 1963·The Journal of Urology·D M SEITZMANK G BARRY
Jul 1, 1963·Anesthesiology·M A HAYES, I S GOLDENBERG
Oct 1, 1963·American Journal of Surgery·K C SAWYERW C ROBB
Jun 25, 1964·The New England Journal of Medicine·K G BARRYF D SCHWARTZ
Dec 1, 1951·The Journal of Clinical Investigation·W E JACOBSONB I HELLER
Apr 1, 1944·Annals of Surgery·F A CollerC A Moyer
Nov 1, 1965·Annals of Surgery·B F RushR J Wilder
Sep 9, 1905·British Medical Journal·H PringleS Pringle
Jun 1, 1951·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·H N DUKEJ A WATT


Sep 1, 1985·Acta Pharmacologica Et Toxicologica·J L PlummerM J Cousins
Sep 2, 2011·American Journal of Veterinary Research·Matthew D WinterDean H Riedesel
Apr 7, 2015·Korean journal of anesthesiology·Byung Moon ChoiKyu Taek Choi
Dec 25, 2012·Current Opinion in Anaesthesiology·Sherif AssaadAlbert Perrino
Aug 1, 1992·Anaesthesia and Intensive Care·G J Duke, A D Bersten

Related Concepts

Anesthesia Procedures
Anesthetic Effect
Drug Interactions
Kidney Diseases
Renal Tubule Structure
Structure of Ascending Limb of Henle's Loop

Related Feeds

Related Papers

European Journal of Anaesthesiology
H Burchardi, G Kaczmarczyk
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A J Howie
Best Practice & Research. Clinical Anaesthesiology
Florian M Reichle, P Conzen
© 2021 Meta ULC. All rights reserved