PMID: 6402282Jan 1, 1983Paper

Anaesthetic induction with alfentanil: comparison with thiopental, midazolam, and etomidate

Canadian Anaesthetists' Society Journal
J NautaJ van Kleef

Abstract

The speed, side effects and cardiovascular changes associated with anaesthetic induction and endotracheal intubation following alfentanil (20 micrograms/kg/min, IV), thiopental (84 micrograms/kg/min, IV), etomidate (5 micrograms/kg/min, IV) and midazolam (20 micrograms/kg/min, IV) prior to halothane-nitrous oxide general anaesthesia were evaluated and compared in 80 patients undergoing elective general surgical operations. Anaesthetic induction was fastest with etomidate and thiopental (approximately one minute) and slowest with midazolam (about two minutes). Systolic arterial blood pressure (SBP) was decreased at the moment of unconsciousness with thiopental but unchanged with the other compounds. Heart rate (HR) was increased at unconsciousness with midazolam and thiopental but unchanged with etomidate and alfentanil. After intubation HR was increased in all groups except those induced with alfentanil. Arrhythmias were infrequent (5 per cent or less in all groups). Rigidity during induction only occurred with alfentanil (55 per cent) and pain on injection only with etomidate (35 per cent) and alfentanil (5 per cent). Postoperative vomiting was infrequent in all groups (15 per cent) except etomidate (55 per cent). No patient r...Continue Reading

References

Sep 1, 1978·Anesthesia and Analgesia·T H StanleyH R Hill
Mar 1, 1976·Anesthesiology·T H StanleyC R Sentker
May 1, 1968·Canadian Anaesthetists' Society Journal·G S FoxM Bhambhami
Nov 1, 1966·Canadian Anaesthetists' Society Journal·A McClish
Dec 1, 1981·British Journal of Anaesthesia·S de LangeM J Boscoe
Mar 1, 1982·Anesthesia and Analgesia·J NautaT H Stanley
Jan 1, 1981·The Journal of Small Animal Practice·R P HappéW T Wolvekamp
Oct 1, 1981·Anesthesiology·A B HillR E Bolles
Jan 1, 1980·Canadian Anaesthetists' Society Journal·A CabanasJ A Aldrete
Jul 1, 1961·Anesthesiology·J W ECKSTEINJ M McCAMMOND

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Citations

Jul 1, 1994·Medical & Biological Engineering & Computing·G Castor
Jul 1, 1983·Canadian Anaesthetists' Society Journal·W SchwinnK Skarvan
Sep 1, 1984·Canadian Anaesthetists' Society Journal·M G PalazzoL Strunin
Jul 1, 1985·Canadian Anaesthetists' Society Journal·J P Dechène
May 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W S SchechterF A Burrows
Apr 13, 1984·European Journal of Pharmacology·J D'AubioulR S Reneman
May 24, 2005·Journal of Pain and Symptom Management·Theodore H Stanley
Mar 1, 1997·The Journal of Emergency Medicine·J M Bergen, D C Smith
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·P M Lauven, P J Kulka
Feb 1, 1985·Acta Anaesthesiologica Scandinavica·M HynynenA M Lehtinen
Jan 1, 1986·Acta Anaesthesiologica Scandinavica·J C Raeder, A Hole
Jan 1, 1987·Annales Françaises D'anesthèsie Et De Rèanimation·J Kienlen, J du Cailar
Jan 7, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jun YangWensheng Zhang
Oct 24, 2006·European Journal of Anaesthesiology·J-T SohnY-K Chung
Sep 1, 1983·Pharmacotherapy·J L Giese, T H Stanley
May 1, 1986·Drug Intelligence & Clinical Pharmacy·J A Reitz

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