Anaesthetic management of a patient with microvillus inclusion disease for intestinal transplantation

Paediatric Anaesthesia
Luis J GoldmanManuel Gámez

Abstract

We report the anaesthetic management of a 3-year-old-child with microvillus inclusion disease undergoing isolated small bowel transplantation. He required long-term total parenteral nutrition which was complicated with numerous episodes of catheter related sepsis. This resulted in thrombosis of the major blood vessels which critically restricted vascular access available for intravenous nutrition, becoming a life-threatening condition for the patient. Haemodynamic, respiratory parameters and urinary output were well preserved throughout the procedure. Besides a transitory increase in potassium following graft revascularization, biochemical changes were small. Anaesthetic management included comprehensive preoperative assessment, central venous angiography to depict accessibility of central and peripheral veins, assurance of additional vascular access through the intraoperative catheterization of the left renal vein, perioperative epidural analgesia and preservation of splanchnic perfusion to ensure implant viability.

References

Jan 1, 1975·Journal of Applied Physiology·E E Johnson
Dec 1, 1989·Gut·A J Watson, P A Lear
Jan 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I MuratC Saint-Maurice
Apr 11, 1980·JAMA : the Journal of the American Medical Association·J AskanaziJ M Kinney
Jul 1, 1997·European Journal of Anaesthesiology·M C BellamyH A O'Beirne
Mar 14, 1998·Journal of Pediatric Surgery·J ReyesT E Starzl
Oct 22, 1998·Critical Care Medicine·E SilvaJ L Vincent
Sep 14, 1999·Journal of Applied Physiology·J A Guzman, J A Kruse
Mar 29, 2000·Paediatric Anaesthesia·P C StewartV L Harrison
Apr 12, 2000·European Journal of Anaesthesiology·K ReinhartA Meier-Hellmann

❮ Previous
Next ❯

Citations

Mar 1, 2012·British Journal of Anaesthesia·T MatsusakiS Aggarwal
Jan 23, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Georgia KostopanagiotouAndreas G Tzakis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.