PMID: 2480088Oct 1, 1989

Anaesthetic-related occurrence of early ventricular arrhythmias during acute myocardial ischaemia in rats

Archives internationales de physiologie et de biochimie
S Dai


The cardiovascular responses of rats anaesthetised with different anaesthetic agents to acute coronary artery ligation were studied. Before thoracotomy, urethane-anaesthetised animals exhibited significantly lower blood pressures. Ligation of the left coronary artery induced a high incidence of ventricular tachycardia or fibrillation in rats anaesthetised with pentobarbitone, urethane, or ether inhalation followed by chloralose. Ketamine-anaesthetised animals had a significantly lower incidence of ventricular arrhythmias. The mortality rate was also lower, though not statistically significant. However, all groups of rats showed essentially similar blood pressure and heart rate changes following coronary artery ligation as well as the time of onset of ventricular tachycardia or fibrillation. The findings demonstrate the influence of anaesthetics on the occurrence of early ventricular arrhythmias following acute coronary artery ligation in rats.


Sep 1, 1978·British Journal of Anaesthesia·A E Waterman, A Livingston
Feb 1, 1986·Clinical and Experimental Pharmacology & Physiology·S C HuiC W Ogle
Apr 1, 1987·Journal of Molecular and Cellular Cardiology·M J CurtisM J Walker
Jan 1, 1986·British Journal of Clinical Pharmacology·J Black


Mar 31, 2010·Journal of Cardiovascular Pharmacology·Michal ZorniakTadeusz F Krzeminski

Related Concepts

Anesthesia Procedures
Cardiac Arrhythmia
Diastolic Blood Pressure
Coronary Heart Disease
Sinus Node Artery
Ethyl ether
Pulse Rate

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