Anal and Cervical High-Risk Human Papillomavirus Genotyping in Women With and Without Genital Neoplasia

Journal of Lower Genital Tract Disease
Amy BregarKatina Robison

Abstract

The aim of the study was to compare the prevalence, genotypes, and rates of concomitant anal and cervical high-risk human papillomavirus (HR-HPV) in women with and without a history of HPV-related genital neoplasia. This was a prospective cohort study conducted from December 2012 to February 2014. Women with a history of neoplasia were considered the high-risk group. Women without a history of neoplasia were considered the low-risk group. Cervical and anal cytology and HPV genotyping were performed. All women with abnormal anal cytology were referred for anoscopy. One hundred eighty-four women met inclusion criteria. High-risk HPV was detected in the anal canal of 17.4% of the high-risk group and 1.5% of the low-risk group (p = .003). High-risk HPV was detected in the cervix of 30.5% of the high-risk group and 7.6% of the low-risk group (p < .001). Concomitant anal and cervical high-risk HPV was detected in 4.4% of the high-risk group and was not detected in the low-risk group (p = .2). Among women with anal intraepithelial neoplasia 2 or greater (n = 5), 60% had HR-HPV detected in the anal canal while none had HR-HPV detected in the cervix. Women with a history of genital neoplasia are more likely to be positive for anal and c...Continue Reading

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Citations

Jan 31, 2021·Revista colombiana de obstetricia y ginecología·Cristhiam David Sánchez-CorredorLuz Amparo Díaz-Cruz
Jan 31, 2021·Revista colombiana de obstetricia y ginecología·Jorge Andrés Rubio-Romero, Luz Amparo Díaz-Cruz

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