PMID: 9170415Apr 15, 1997Paper

Anal cytology as a screening tool for anal squamous intraepithelial lesions

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
J M PalefskyT M Darragh

Abstract

Anal squamous intraepithelial lesions (ASIL) are common in homosexual and bisexual men, and high-grade ASIL (HSIL) in particular may represent an anal cancer precursor. Cervical cytology is a useful screening tool for detection of cervical HSIL to prevent cervical cancer. To assess anal cytology as a screening tool for anal disease, we compared anal cytology with anoscopy and histopathology of anal biopsies. A total of 2958 anal examinations were performed on 407 HIV-positive and 251 HIV-negative homosexual or bisexual men participating in a prospective study of ASIL. The examination consisted of a swab for anal cytology and anoscopy with 3% acetic acid and biopsy of visible lesions. Defining abnormal cytology as including atypical squamous cells of undetermined significance and ASIL, the sensitivity of anal cytology for detection of biopsy-proven ASIL was 69% (95% confidence interval: 60 to 78) in HIV-positive and 47% (95% confidence interval; 26 to 68) in HIV-negative men at their first visit and was 81% and 50%, respectively, for all subsequent visits combined. The absence of columnar cells did not affect the sensitivity, specificity, or predictive value of anal cytology. Anal cytology may be a useful screening tool to detec...Continue Reading

References

Jan 1, 1991·Diagnostic Cytopathology·M G JosephF R Marks
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·A M BeckmannT G Hislop
Nov 15, 1989·Journal of the National Cancer Institute·E A HollyJ J Kristiansen
Oct 15, 1987·The New England Journal of Medicine·J R DalingL Corey
Jan 11, 1986·Lancet·J E McNealT A Stamey
Apr 1, 1987·Journal of Clinical Pathology·Y van der Graaf, G P Vooijs
Nov 16, 1994·Journal of the National Cancer Institute·C S Rabkin, F Yellin
Feb 1, 1994·Genitourinary Medicine·A de RuiterA Mindel

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Citations

Mar 9, 2011·Diseases of the Colon and Rectum·Daniela Cerqueira KoppeRenato Borges Fagundes
Nov 22, 2007·Diseases of the Colon and Rectum·Florian RokaAndreas Salat
Nov 22, 2007·Diseases of the Colon and Rectum·Phillip R FleshnerUNKNOWN Standards Practice Task Force, American Society of Colon and Rectal Surgeons
May 31, 2008·Current HIV/AIDS Reports·Joel Palefsky
Nov 30, 2011·Current Infectious Disease Reports·Subhashis Mitra, Lawrence Crane
Nov 26, 2002·Virus Research·Silvia de Sanjosé, Joel Palefsky
Mar 7, 2002·Critical Reviews in Oncology/hematology·Umberto TirelliEmanuela Vaccher
Jul 6, 2002·Critical Reviews in Oncology/hematology·Lisa LicitraMichel Ducreux
May 4, 2010·Clinics in Colon and Rectal Surgery·Carlos E Pineda, Mark L Welton
Sep 4, 2012·Clinics in Colon and Rectal Surgery·Shawn P Webb, Chong S Lee
Sep 4, 2012·Clinics in Colon and Rectal Surgery·Juan Lucas Poggio
Nov 14, 1997·The New England Journal of Medicine·K V Shah
Dec 13, 2005·Sexual Health·Jonathan StC AndersonAndrew E Grulich
Jun 16, 2012·Sexual Health·Steve Simpson, Richard Turner
Sep 7, 2012·Sexual Health·Teresa M Darragh, Barbara Winkler
Feb 6, 2013·Sexual Health·Andrew E GrulichChristopher K Fairley
Sep 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J WileyLynne Fukumoto
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter V Chin-Hong, Joel M Palefsky
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lori A PantherBruce J Dezube
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth Y ChiaoHashem El Serag
Jun 8, 2001·Journal of the National Cancer Institute·E A HollyJ M Palefsky
Jun 19, 2008·Journal of Public Health·Jonathan KarnonKevin J Smith
Apr 3, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J M PalefskyT M Darragh
Apr 3, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J M PalefskyT M Darragh
Jun 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ross D CranstonJoel M Palefsky
Dec 4, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·William Christopher MathewsUnyeong Go
Dec 8, 2009·Diseases of the Colon and Rectum·J Michael Berry, Joel M Palefsky
Apr 25, 2009·The Nurse Practitioner·Michael D Greene
Sep 10, 2011·Diseases of the Colon and Rectum·Robert N GoldstoneStephen E Goldstone
Jun 19, 2012·Diseases of the Colon and Rectum·Scott R SteeleUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons
Nov 9, 2012·Diseases of the Colon and Rectum·Alexander O MallariRoberto B Corales
Nov 21, 2009·AIDS·Liron Pantanowitz, Bruce J Dezube
Dec 25, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth A StierJoel M Palefsky
Jan 28, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·James H WilligEduardo Gotuzzo
Sep 29, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mark Drew Crosland GuimarãesJoel M Palefsky

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