Anal lymphogranuloma venereum infection screening with IgA anti-Chlamydia trachomatis-specific major outer membrane protein serology

Sexually Transmitted Diseases
Henry J C de VriesServaas A Morré

Abstract

Anal lymphogranuloma venereum (LGV) infections, caused by Chlamydia trachomatis biovar L (Ct+/LGV+), are endemic among men who have sex with men (MSM). Anal non-LGV biovar Ct infections (Ct+/LGV-) can be eradicated with 1 week doxycycline, whereas Ct+/LGV+ infections require 3-week doxycycline. To differentiate Ct+/LGV+ from Ct+/LGV- infections, biovar-specific Nucleic Acid Amplification Test (NAAT) are standard, but also expensive and laborious. A chlamydia-specific serological assay could serve as an alternative test. MSM were screened for anal Ct+/LGV+ and Ct+/LGV- infections with a commercial nonspecific NAAT and an in house biovar L-specific NAAT. Serum samples were evaluated with chlamydia-specific anti-Major Outer Membrane Protein (MOMP) and antilipopolysaccharide assays of IgA and IgG classes. Asymptomatic patients were identified as: (1) no anal complaints or (2) no microscopic inflammation (i.e., <10 leucocytes per high power field in anal smears). The best differentiating assay was subsequently evaluated in 100 Ct+/LGV+ and 100 Ct+/LGV- MSM using different cut-off points. The anti-MOMP IgA assay was the most accurate to differentiate Ct+/LGV+ (n = 42) from Ct+/LGV- (n = 19) with 85.7% sensitivity (95% confidence inte...Continue Reading

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Jul 24, 2008·Sexually Transmitted Infections·Servaas A MorréHenry J C de Vries
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Citations

Feb 25, 2014·Clinics in Dermatology·Henry J C de Vries
Oct 22, 2015·American Journal of Clinical Pathology·Christina A ArnoldLysandra Voltaggio
Nov 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bradley P Stoner, Stephanie E Cohen
Mar 26, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·H J C de VriesJ A White
Apr 24, 2014·Obstetrics and Gynecology International·Ingrid V F van den BroekMarianne A B van der Sande
Apr 23, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Spornraft-RagallerS Esser
Sep 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O PeuchantB de Barbeyrac
Dec 20, 2013·International Journal of STD & AIDS·Henry Jc de VriesAlexander Kreuter
Nov 27, 2015·International Journal of STD & AIDS·E LanjouwM Unemo
Oct 27, 2010·International Journal of STD & AIDS·H J C de VriesH Moi
Mar 25, 2014·Expert Review of Anti-infective Therapy·Nynke Hesselina Neeltje de Vrieze, Henry John Christiaan de Vries
Dec 1, 2012·British Journal of Nursing : BJN·Joel Zamora PaparelloJitna Por
Jun 28, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·H J C de VriesM Unemo
Jun 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·H J C de VriesJ Ross
Jun 12, 2014·BMC Research Notes·Marlies HeiligenbergMaarten F Schim van der Loeff

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