Analgesia and other causes of amnesia that mimic post-traumatic amnesia (PTA): a cohort study

Journal of Neuropsychology
Steven KempAnthony K Coughlan

Abstract

This study explores the possibility that a post-traumatic amnesia (PTA) like phenomenon is caused by the administration of drugs in hospital following injury and that this may be observed in patients who have not suffered a traumatic brain injury (TBI). This work also explored the possibility for an additional contribution to this phenomenon of demographic and psychological variables. Sixty-three orthopaedic patients with no evidence of brain injury were recruited to a two-phase study. Medication records, demographic, and psychological data were obtained at the phase 1. At follow-up interviews (phase 2), psychological data (mood and post-traumatic stress disorder, PTSD) were again obtained and retrospective assessment of PTA using the Rivermead PTA protocol was carried out in 47 patients. Thirty-eight per cent (N=18) of the total sample (N=47) reported a PTA-like phenomenon despite not having suffered TBI. A logistic regression model including the receipt of opioids, surgery, and anxiety-related variables, was significant in predicting this phenomenon (χ²=22.054, df=4, p≤.01) and accounted for up to 57.5% of variation in the data. Age, either alone or in interaction with opioid use, depression, and PTSD symptoms were not signif...Continue Reading

References

Apr 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·T M McMillanR J Greenwood
Jan 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·N S KingF E Caldwell
Nov 14, 1997·The American Journal of Psychiatry·P RohdeJ R Seeley
Nov 3, 1997·Quality in Health Care : QHC·A RobinsB W Lloyd
Jan 7, 2004·Behaviour Research and Therapy·Mark CreamerSalvina Failla
May 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Ruth E Sumpter, Tom M McMillan
Feb 18, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Richard J McNally
Oct 12, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·M ShererT G Nick
Feb 1, 2008·The New England Journal of Medicine·Charles W HogeCarl A Castro

❮ Previous
Next ❯

Citations

Feb 19, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Daniel Friedland, Michael Swash

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.