PMID: 22580524May 15, 2012Paper

Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients with pain

Pharmacological Reports : PR
Wojciech LeppertMichał Szulc

Abstract

Aim of the study was to assess dihydrocodeine (DHC) and metabolites concentrations and their correlations with DHC analgesia in cancer patients with pain. Thirty opioid-naive patients with nociceptive pain intensity assessed by VAS (visual analogue scale) > 40 received controlled-release DHC as the first (15 patients, 7 days) or as the second opioid (15 patients, 7 days). Blood samples were taken on day 2, 4 and 7 at each study period. DHC and its metabolites were assayed by HPLC. DHC provided satisfactory analgesia when administered as the first or the second opioid superior to that of tramadol. When DHC was the first opioid administered, DHC and dihydrocodeine-6-glucuronide (DHC-6-G) concentrations increased in the second and the third comparing to the first assay. A trend of nordihydromorphine (NDHM) level fall between the first and the third assay was noted; trends of dihydromorphine (DHM) level increase in the second relative to the first determination and decrease in the third compared to the second assay were observed. When DHC followed tramadol treatment a trend of DHC concentration increase in the second relative to the first assay was noted. DHC-6-G level increased in the second and in the third comparing to the first...Continue Reading

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Citations

Dec 23, 2015·Journal of Chromatographic Science·Wei-min ZhangZhi-yin Zhang
May 13, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiangjun QiuNan-sheng Zhang
Aug 21, 2013·Pharmacological Reports : PR·Li-Hua HangHong Wang

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