PMID: 6539479Jan 1, 1984Paper

Analgesia induced by painful stimulation and/or anticipation of pain; different mechanisms are operating

Physiologia Bohemoslovaca
B Jakoubek

Abstract

Various stresses (i.e. transfer stress, exposition of animals to a new environment, footshock stress, anticipation stress) were found to produce hypalgesia as judged from an increase of the tail - flick latency in rats. Hypalgesia induced by transfer stress was slightly reduced by diazepam (5 mg per kg), but very significantly by chlorpromazine (5 mg per kg). Footshock-stress-induced analgesia lasted less than 15 min. Because naloxone or dexamethasone did not block the footshock-induced analgesia, the participation of the endorphinergic system in this form of stress-induced analgesia is not probable. During the 30 min lasting conditioned reaction to footshock administration (called here anticipation stress), marked analgesia was observed. This anticipation-stress-induced analgesia was blocked by naloxone, dexamethasone and chlorpromazine; no blockade was observed after diazepam. These observations suggest that the endorphinergic system in this form plays a role in stress-induced analgesia. The comparison of the effects of naloxone and/or dexamethasone on the analgesia induced by footshock on the one hand and analgesia induced by anticipation stress on the other thus suggests that different antinociceptive mechanisms are activat...Continue Reading

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