Analgesic activity of Heliopsis longipes and its effect on the nervous system

Pharmaceutical Biology
V G Cilia-LópezJ A Reyes-Agüero

Abstract

Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system (NS) have not been investigated yet. The objectives of this study were to evaluate the analgesic action of affinin and the H. longipes root ethanol extract, as well as their effects on the NS using an animal model. The ethanol extract was obtained by maceration, and affinin was purified from it through chromatographic techniques. Chemical and thermal analgesia were used to assess their analgesic proprieties. Irwin's test was used to evaluate their stimulating or depressing effects. The ethanol extract and affinin displayed analgesic action similar to ketorolac and stimulating effect comparable to caffeine on the nervous system of adult mice.

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Citations

Jun 7, 2013·Pharmaceutical Biology·Myriam Arriaga-AlbaMyrna Déciga-Campos
Sep 15, 2016·PloS One·Verônica Santana de Freitas-BlancoRodney Alexandre Ferreira Rodrigues
Jan 25, 2017·International Journal of Molecular Sciences·Jesús Eduardo Castro-RuizCésar Ibarra-Alvarado
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Gisele Custodio de SouzaJosé Carlos Tavares Carvalho

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