Analgesic Activity of Hexaazaisowurtzitane Derivatives

Bulletin of Experimental Biology and Medicine
S G KrylovaV V Zhdanov

Abstract

Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,03, 11,05, 9] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.

References

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Jun 2, 2011·Topics in Current Chemistry·Hiroshi Nagase, Hideaki Fujii
Sep 21, 2011·Current Medical Research and Opinion·Giustino Varrassi
Jan 17, 2012·Neuroscience·M Barrot

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