Analgesic and anti-inflammatory activities of Citrus aurantium L. blossoms essential oil (neroli): involvement of the nitric oxide/cyclic-guanosine monophosphate pathway

Journal of Natural Medicines
Pariya KhodabakhshJinous Asgarpanah

Abstract

The analgesic and anti-inflammatory properties of Citrus aurantium L. blossoms essential oil (neroli) were investigated in mice and rats. The analgesic activity of neroli was assessed by acetic acid-induced writhing and Eddy's hot plate methods, while acute and chronic anti-inflammatory effects were investigated by inflammatory paw edema in rat and the cotton pellet-induced granuloma tissue model, respectively. Mechanistic studies were conducted using L-nitro arginine methyl ester (L-NAME), an inhibitor of NO synthase. Neroli significantly decreased the number of acetic acid-induced writhes in mice compared to animals that received vehicle only. Also, it exhibited a central analgesic effect, as evidenced by a significant increase in reaction time in the hot plate method. The oil also significantly reduced carrageenan-induced paw edema in rats. The inhibitory activity of neroli (especially at 40 mg/kg) was found to be very close to the standard drug, diclofenac sodium (50 mg/kg). In cotton pellet-induced granuloma, neroli was effective regarding the transudate and granuloma formation amount. Neroli was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) and twenty-three constituents, representing...Continue Reading

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Citations

Jan 19, 2016·International Immunopharmacology·Haijing ZhangWenjie Wang
Mar 14, 2018·Nutrition Reviews·Ewelina KurtysErik F J de Vries
Jun 19, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Farhad MoslemiMohammad Reza Heidari
Jul 7, 2018·International Journal of Molecular Sciences·Noura S Dosoky, William N Setzer
Jan 24, 2019·Oxidative Medicine and Cellular Longevity·Érica Martins de LavorJackson Roberto Guedes da Silva Almeida
Apr 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Kai SunYi Yang
Mar 19, 2021·Frontiers in Pharmacology·Damiana ScuteriMaria Tiziana Corasaniti
Jun 16, 2021·Journal of Ethnopharmacology·Matthias S GeckMarco Leonti
Sep 15, 2017·Journal of Agricultural and Food Chemistry·Chun-Yan ShenQin Ou-Yang

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