Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba

Journal of Integrative Medicine
Mesfin YimamQi Jia

Abstract

Though the initial etiologies of arthritis are multifactorial, clinically, patients share the prime complaints of the disease, pain. Here the authors assessed the analgesic and anti-inflammatory effects of UP1304, a composite that contains a standardized blend of extracts from the rhizome of Curcuma longa and the root bark of Morus alba, on rats with carrageenan-induced paw edema. A plant library was screened for bradykinin receptor antagonists. In vivo, the anti-inflammatory and analgesic effects of the standardized composite, UP1304, were evaluated in rats with carrageenan-induced paw edema using oral dose ranges of 100-400 mg/kg. Ibuprofen, at a dose of 200 mg/kg, was used as a reference compound. In vitro, cyclooxygenase (COX) and lipoxygenase (LOX) inhibition assays were performed to evaluate the degree of inflammation. Statistically significant improvements in pain resistance and paw edema suppression were observed in animals treated with UP1304, when compared to vehicle-treated rats. Results from the highest dose of UP1304 (400 mg/kg) were similar to those achieved by ibuprofen treatment at 200 mg/kg. In vitro, UP1304 showed dose-dependent inhibition of the enzymatic activities of COX and LOX. A half-maximal inhibitory c...Continue Reading

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Citations

Mar 8, 2017·Scientific Reports·Xiuzhong QiLina Wang
Dec 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hu ChenNingjia He
Sep 12, 2019·BMC Complementary and Alternative Medicine·Wendy Pearson, Laima S Kott
Nov 3, 2020·Food Science & Nutrition·Fatemeh BabaeiHossein Hosseinzadeh
Jan 6, 2021·Plants·Md Moshiur RahamanJesus Simal-Gandara

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