Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals

Journal of Ethnopharmacology
Kyung-Hee Lee, Eun-Mi Choi

Abstract

The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice. Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid. The acute treatment of mice with LF at doses of 100 and 200mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice. These inhibitions were statistically significant (P<0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain.

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Citations

Jul 16, 2010·Marine Drugs·João C FernandesJoão E Carvalho
Jul 15, 2015·Experimental and Therapeutic Medicine·Biao LuoYahui Wei
Jun 4, 2014·Chemico-biological Interactions·Ha Neul LeeDong-Wan Seo
Feb 26, 2019·Journal of Medicinal Food·Ju-Hyoung ParkJoa Sub Oh
Aug 9, 2021·Journal of Ethnopharmacology·Xiaopei YangYunsheng Xu

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