Analgesic and Cardiopulmonary Effects of Epidural Romifidine and Morphine Combination in Horses.

Journal of Equine Veterinary Science
Claudio C NataliniAlexandre da S Polydoro

Abstract

The study aim is to compare the effects of epidural administration of two different doses of romifidine combined with morphine in horses. A prospective crossover blinded experimental design was used. Five adult healthy horses two males and three females with a mean body weight of 380 ± 45 Kg (335-425 kg), were studied. Treatments consisted of romifidine 30 μg/kg (R30) or 60 μg/kg (R60) combined with morphine 0.1 mg/kg with a washout interval of 72 hours, administered through an epidural catheter placed at the first intercoccygeal space. Heart rate (HR) and respiratory rate (fR), pH, blood gases, arterial blood pressures (mmHg), and threshold for electrical noxious stimulation was evaluated for 120 minutes and after 240 minutes of epidural injection. Data were collected before injections and every 15 minutes for 120 minutes, and at 240 minutes of epidural administration. Significant sedation occurred in both treatments with no statistically significant difference between them. There were significant changes in fR and HR from baseline but no difference between treatments. Arterial blood pressures were significantly lower in R60 treatment from 75 up to 120 minutes post epidural injection. Analgesia was considered moderate for both...Continue Reading

References

Apr 1, 1992·Journal of Pharmacological and Toxicological Methods·F MedzihradskyC A Mousigian
May 1, 1990·Equine Veterinary Journal·P H LeBlanc, J P Caron
Jun 1, 1994·Anesthesia and Analgesia·R E Solomon, G F Gebhart
Nov 1, 1996·The British Veterinary Journal·G C England, K W Clarke
May 25, 2002·Research in Veterinary Science·S L FreemanG C W England
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·David A Daunt, Eugene P Steffey
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·Elaine P Robinson, Claudio C Natalini
Sep 23, 2003·Veterinary Anaesthesia and Analgesia·Veronika H Olbrich, Martina Mosing
Jan 18, 2005·Equine Veterinary Journal·R Bettschart-WolfensbergerK W Clarke
Dec 13, 2005·American Journal of Veterinary Research·Claudia SpadavecchiaUrs Schatzmann
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Alexander Valverde
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Claudio C Natalini
Jul 22, 2014·Veterinary Anaesthesia and Analgesia·Giovanna L CostaClaudia Interlandi
Dec 24, 2014·The Journal of Emergency Medicine·Dazhe CaoAlex Koyfman

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