Analgesic and cytotoxic activity of Acorus calamus L., Kigelia pinnata L., Mangifera indica L. and Tabernaemontana divaricata L.

Journal of Pharmacy & Bioallied Sciences
Mohammad Ahad Ali Khan, Mohammad Torequl Islam

Abstract

The aim of the study was to evaluate analgesic and cytotoxic activity of Acorus calamus L., Kigelia pinnata L., Mangifera indica L., Tabernaemontana divaricata L. extracts by using acetic acid-induced writhing method in mice and brine shrimp lethality assay. The ethanolic extracts of the plants were obtained by simple maceration method and were subjected to standardization by using pharmacognostical and phytochemical screening methods, which were followed by acetic acid writhing and brine shrimp lethality test methods. Dose selection was made on the basis of acute oral toxicity study (10-1000 mg/kg body weight). In analgesic test, M. indica L. extract produced 28.16% and 22.02% writhing protection at the doses of 250 and 500 mg/kg body weight in mice, respectively. While the T. divaricata L. extract produced 22.02% and 33.93%, K. pinnata L. extract produced 11.55% and 47.29% and A. calamus L. extract produced 15.16% and 54.51% of writhing protection at the same doses. The percent mortality (mean ± SD) was found to be 58.7 ± 25.22, 56.25 ± 22.88, 52.50 ± 24.37, and 61.25 ± 26.66 with M. indica L., T. divaricata L., K. pinnata L., and A. calamus L., respectively. And the LC(50) and LC(90) values were found to be 100 and 300 μg/mL...Continue Reading

Citations

Oct 10, 2013·Pharmaceutical Biology·Umesh C S Yadav, Najma Z Baquer
Nov 16, 2014·Rheumatology International·Mohammad Hosein FarzaeiAmir Hossein Abdolghaffari
Feb 25, 2014·BMC Complementary and Alternative Medicine·Khalid Hussain JanbazVincenzo De Feo
Jan 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Patrick AmoatengAlexander K Nyarko

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