PMID: 9530988Apr 8, 1998Paper

Analgesic and thermic effects, and cerebrospinal fluid and plasma pharmacokinetics, of intracerebroventricularly administered morphine in normal and sensitized rats

The Journal of Pharmacy and Pharmacology
H N BhargavaE J Morcillo

Abstract

The relationship between asthma and opioids has barely been investigated. This study examines whether active sensitization of rats changes the analgesic and thermic effects of intracerebroventricular morphine or the pharmacokinetics of the drug. Morphine (5, 10 and 20 microg) was given intracerebroventricularly to sensitized (active immunization to ovalbumin and Al(OH)3 then airway challenge with ovalbumin after 12 days) and normal (i.e. non-sensitized) male Sprague-Dawley rats. The tail-flick latencies and changes in colon temperature were determined before morphine injection and at 30 min intervals for a period of 300 min afterwards. Results were expressed as the area under the time-response curve. The analgesic and hyperthermic response to morphine for sensitized rats was less than that obtained for normal rats. Cerebrospinal fluid and blood samples were collected periodically for a period of 240 min and morphine levels were determined by a highly sensitive radioimmunoassay. The pharmacokinetic parameters half-life, terminal elimination rate constant and the mean residence time were determined in both cerebrospinal fluid and plasma by non-compartmental analysis. The area under the cerebrospinal fluid concentration-time curve...Continue Reading

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Citations

Jul 27, 2010·European Journal of Pharmacology·Adriana Miriam Domínguez-RamírezFrancisco Javier López-Muñoz
Jun 29, 2001·The Journal of Pharmacy and Pharmacology·V M VillarM J Groves
Feb 22, 2017·The Journal of Pharmacy and Pharmacology·Patricia Esmeralda Carrillo-CalzadillaAdriana Miriam Domínguez-Ramírez

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