Analgesic, anti-inflammatory and antipyretic activities of the methanol leaf extract of Dalbergia saxatilis Hook.F in rats and mice

Journal of Ethnopharmacology
F Ismail HassanU Habib Danmalam

Abstract

The decoction of the leaves of Dalbegia saxatilis is used in Traditional Medicine for various ailments such as cough, small pox, skin lesions, bronchial ailments and toothache. The study is aimed at evaluating the analgesic, anti-inflammatory, and antipyretic effects of D. saxatilis to provide scientific basis for its use. Phytochemical screening and evaluation of oral median lethal dose was carried out on the methanol leaf extract of the plant. Analgesic activity using acetic acid induced writhing and hot plate method in mice, anti-inflammatory activity using carrageenan induced paw oedema in rats, and antipyretic activity using Brewer׳s yeast induced pyrexia in rats were evaluated at 250mg/kg, 500mg/kg, and 1000mg/kg doses of the extract. The oral median lethal dose was found to be above 5000mg/kg. The extract was found to contain alkaloids, flavonoids, tannins, saponins, cardiac glycosides, and triterpenes. The extract and the standard drug (Aspirin) significantly decreased the number of writhes caused by acetic acid at p<0.001. There was statistical significant increase in reaction time in standard group, extract 250mg/kg, and 1000mg/kg from 60min at p<0.05 and p<0.01, from 30min in 500mg/kg group at p<0.05 and p<0.01 compa...Continue Reading

References

Dec 1, 1983·Archives of Toxicology·D Lorke
Nov 11, 1999·British Journal of Pharmacology·F NantelC C Chan
Nov 1, 2003·Thrombosis Research·J R Vane, R M Botting
Oct 27, 2009·Journal of Ethnopharmacology·Haroon KhanInamullah Khan
Sep 21, 2011·Current Medical Research and Opinion·Joseph Pergolizzi
Oct 1, 2009·Avicenna Journal of Medical Biotechnology·Bagepalli Srinivas Ashok KumarBachappa Manoj
Jun 24, 2014·Journal of Tropical Medicine·Samuel Okwudili OnojaMartins Ndubuisi Chukwu

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Citations

Nov 22, 2017·Archives of Physiology and Biochemistry·Raouia DhouibiHanen Affes

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