PMID: 8336989May 1, 1993Paper

Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine

Pain
M PappagalloP A Gioffrè

Abstract

Adenosine is known to cause pain when injected intravenously or intra-arterially. We have conducted a double-blind placebo-controlled study by injecting adenosine intradermally in 6 healthy subjects (5 male, 1 female; age: 27-34 years). Pain was assessed using the visual analogue scale. The intradermal injection of 2 mumol of adenosine produced pain significantly greater than normal saline after 15 sec (T0) (29 +/- 13 vs. 7 +/- 6 mm, P = 0.004), 1 min after T0 (13 +/- 9 vs. 0 +/- 0 mm, P = 0.002) and 2 min after T0 (4.5 +/- 5 vs. 0 +/- 0 mm, P < 0.05). There was evidence of hyperalgesia to mechanical and heat stimuli at the injection site (primary hyperalgesia). There was no evidence of mechanical hyperalgesia in the cutaneous area surrounding the injected site (secondary hyperalgesia). In all cases the intradermal injection of adenosine produced local hyperemia (mean surface are: 147 +/- 69 mm2) which was absent after placebo injection. The pre-injection of bamiphylline, a rather selective antagonist of A1 adenosine receptors, differently from placebo, completely suppressed the adenosine-induced pain after 15 sec (T0) (15 +/- 10 vs. 0 +/- 0 mm, P = 0.002) and 1 min after T0 (9 +/- 7 vs. 0 +/- 0 mm, P = 0.002). No anesthesia to...Continue Reading

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Citations

Nov 1, 1993·Cardiovascular Drugs and Therapy·C Sylvén
Dec 1, 1993·Journal of the American College of Cardiology·F TomaiP A Gioffrè
Jan 1, 1995·Journal of the American College of Cardiology·A GaspardoneP A Gioffrè
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Nov 7, 2000·Acta Anaesthesiologica Scandinavica·V Dahl, J C Raeder
Aug 1, 1995·Acta Anaesthesiologica Scandinavica·A EkblomA Sollevi
Apr 1, 1997·Acta Anaesthesiologica Scandinavica·M SegerdahlA Sollevi
Dec 15, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·F RuM Kollarik
Mar 21, 2012·The Canadian Journal of Cardiology·Stuart D Rosen
Jul 4, 2009·Acta Anaesthesiologica Scandinavica·J DellermalmS Grass
May 21, 2016·British Journal of Clinical Pharmacology·Guido van AmerongenJustin L Hay
Dec 13, 1997·Circulation·F Crea, A Gaspardone
Feb 23, 2007·The American Journal of Gastroenterology·Satish S C RaoBridget Zimmerman
Sep 18, 2009·Sports Medicine·J K Davis, J Matt Green
Mar 5, 2003·Pharmacological Reviews·Jana Sawynok
Jun 26, 1999·British Journal of Clinical Pharmacology·R A SeymourC Andrews

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