Analgesic effect of epidural neostigmine after abdominal hysterectomy

Journal of Clinical Anesthesia
M NakayamaA Namiki

Abstract

To evaluate the effects of epidurally administered neostigmine on pain after abdominal hysterectomy. Prospective, randomized, double-blind study. Teaching hospital. 45 ASA physical status I adult patients scheduled for abdominal hysterectomy. All patients received identical general and epidural anesthesia. At the end of the surgery, they received epidural bupivacaine (10 mg) with either saline (control group, n = 15), 5 micro g/kg (5-micro g group, n = 15), or 10 micro g/kg neostigmine (10-micro g group, n = 15). Postoperatively, 50 mg diclofenac suppository was given for pain relief on patient demand. The time to first diclofenac administration and the number of times diclofenac was required during the first 24 postoperative hours were recorded. Pain was assessed using a 10-cm visual analog pain scale (VAS) at rest at the first diclofenac request, and at 15 and 24 hours after surgery. The time to first diclofenac administration was significantly longer (p < 0.05) in the 10-micro g group (223 +/- 15 min) than in the control (78 +/- 17 min) or 5-micro g groups (88 +/- 18 min). However, epidural neostigmine at both doses did not reduce the number of postoperative diclofenac administrations. There were no differences in VAS among ...Continue Reading

References

Oct 29, 1985·European Journal of Pharmacology·T L YakshG J Harty
Jul 27, 1981·Brain Research·J K WamsleyM J Kuhar
Jun 1, 1995·Anesthesia and Analgesia·H BouazizJ C Eisenach
Jun 1, 1997·Anesthesia and Analgesia·J A KrukowskiR L Parker
Sep 1, 1997·Journal of Clinical Anesthesia·G R LaurettiW A Prado

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Citations

Dec 31, 2004·Current Pain and Headache Reports·James W Heitz, Eugene R Viscusi
Aug 29, 2012·American Journal of Veterinary Research·Rafael DeRossiRonaldo C Pagliosa
Dec 30, 2014·Indian Journal of Pharmacology·Qiao Sheng ZhongZhang Gang Xue
Jan 6, 2015·Saudi Journal of Anaesthesia·Gabriela Rocha Lauretti
Dec 18, 2009·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Yuan-Yi ChiaKang Liu
Jul 24, 2010·Journal of Clinical Anesthesia·Divya Sethi, Rama Wason
May 20, 2003·Paediatric Anaesthesia·Dilek MemişZafer Pamukçu
Dec 14, 2004·Journal of Clinical Anesthesia·Eiji MasakiMasato Matsushima
Mar 15, 2005·Anesthesiology Clinics of North America·Ashraf S Habib, Tong J Gan
Mar 5, 2009·Neurourology and Urodynamics·Mayank Mohan AgarwalArup Kumar Mandal
Feb 28, 2003·Anesthesiology·Alparslan TuranNecdet Süt
Mar 26, 2003·Anesthesia and Analgesia·Fabienne RoelantsPatricia Lavand'homme
Jun 1, 2006·Current Opinion in Anaesthesiology·Fabienne Roelants
Jun 1, 2006·Current Opinion in Anaesthesiology·Patricia Lavand'homme
Dec 22, 2005·Anesthesia and Analgesia·Yuan-Yi ChiaYing-Ming Wang
Jul 28, 2004·Anesthesiology·Dan Benhamou
Jul 28, 2004·Anesthesiology·Fabienne Roelants, Patricia M Lavand'homme
Nov 29, 2002·Anesthesia and Analgesia·Maruãn OmaisCleber A J Paccola

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