Analgesic Effect of the Newly Developed S(+)-Flurbiprofen Plaster on Inflammatory Pain in a Rat Adjuvant-Induced Arthritis Model

Drug Development Research
Masanori SugimotoHideo Matsumoto

Abstract

Preclinical Research This article describes the properties of a novel topical NSAID (Nonsteroidal anti-inflammatory drug) patch, SFPP (S(+)-flurbiprofen plaster), containing the potent cyclooxygenase (COX) inhibitor, S(+)-flurbiprofen (SFP). The present studies were conducted to confirm human COX inhibition and absorption of SFP and to evaluate the analgesic efficacy of SFPP in a rat adjuvant-induced arthritis (AIA) model. COX inhibition by SFP, ketoprofen and loxoprofen was evaluated using human recombinant COX proteins. Absorption of SFPP, ketoprofen and loxoprofen from patches through rat skin was assessed 24 h after application. The AIA model was induced by injecting Mycobacterium tuberculosis followed 20 days later by the evaluation of the prostaglandin PGE2 content of the inflamed paw and the pain threshold. SFP exhibited more potent inhibitory activity against COX-1 (IC50  = 8.97 nM) and COX-2 (IC50  = 2.94 nM) than the other NSAIDs evaluated. Absorption of SFP was 92.9%, greater than that of ketoprofen and loxoprofen from their respective patches. Application of SFPP decreased PGE2 content from 15 min to 6 h and reduced paw hyperalgesia compared with the control, ketoprofen and loxoprofen patches. SFPP showed analgesic ...Continue Reading

References

Jun 1, 1975·Chemical & Pharmaceutical Bulletin·S Kuzuna, K Kawai
Apr 1, 1975·European Journal of Pharmacology·A W PircioM E Bierwagen
Apr 1, 1995·Journal of Clinical Pharmacy and Therapeutics·A M TaburetE Leutenegger
Jun 1, 1996·Journal of Clinical Pharmacology·A CarabazaD Mauleón
Apr 24, 1999·The Biochemical Journal·J K GierseP C Isakson
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi
Dec 21, 2000·Current Rheumatology Reports·A R AminS B Abramson
Aug 20, 2004·BMC Musculoskeletal Disorders·Lorna MasonHenry J McQuay
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Masahiro NoguchiMasao Sasamata
Nov 7, 2009·Journal of Pharmaceutical Sciences·Xu MaZhonggui He
Nov 24, 2011·Pain Research and Treatment·Henning Zeidler
Sep 19, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Takaaki Komatsu, Tsukasa Sakurada

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Citations

Jun 1, 2016·Drug Development Research·Ricardo Liévano-ReyesFrancisco Javier López-Muñoz
Apr 6, 2017·Clinical and Experimental Nephrology·Noboru OtsukaYoshio Terada
Jan 11, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·On TakedaEiichi Tsuda
May 16, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Noboru Otsuka, Ikuko Yataba
Sep 7, 2018·Experimental and Therapeutic Medicine·Numan KaraarslanOzkan Ates
Dec 3, 2020·Scientific Reports·Komal ZiaZaheer Ul-Haq

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