PMID: 9549654Apr 29, 1998Paper

Analgesic efficacy and safety of (R)- ketoprofen in postoperative dental pain

Journal of Clinical Pharmacology
S A CooperE V Hersh

Abstract

This double-blind, randomized, parallel-group study compared the analgesic efficacy and safety of single doses of (R)- ketoprofen 25 mg and 100 mg to that of acetaminophen 1,000 mg and placebo in 177 patients experiencing moderate to severe pain after surgical removal of their impacted third molars. Both (R)- ketoprofen 100 mg and acetaminophen 1,000 mg were significantly (P < 0.05) more efficacious than placebo for all summary analgesic measures. Other than a more rapid analgesic onset (45 minutes versus 60 minutes) for acetaminophen 1,000 mg, (R)- ketoprofen 100 mg and acetaminophen 1,000 mg were statistically equivalent to each other. The 25 mg dose of (R)- ketoprofen appeared to approach the analgesic threshold dose, being numerically but not statistically superior to placebo for all summary measures. There were no serious adverse events observed in this study, with the overall incidence of side effects being somewhat less in the (R)- ketoprofen groups than in the acetaminophen 1,000 mg group. (R)- Ketoprofen possesses analgesic activity and an acceptable side-effect profile in the oral surgery pain model.

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Citations

Sep 15, 1999·Clinical Therapeutics·E V HershA Appel
Jun 26, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·John R ZunigaCharles Bon
Aug 1, 2002·The Journal of the American Dental Association·Donald R Mehlisch
Jan 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·M F LandoniP Lees
Apr 10, 2002·American Journal of Therapeutics·Henry J McQuayR Andrew Moore
Mar 24, 2018·Current Medical Research and Opinion·Magdi Hanna, Jee Y Moon
Dec 20, 2007·Chirality·Małgorzata Zielińska-PrzyjemskaJoanna Klaczyńska
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Laurence TomsR Andrew Moore
May 26, 2017·The Cochrane Database of Systematic Reviews·Helen GaskellR Andrew Moore
Dec 1, 1998·Journal of Clinical Pharmacology·Mark McGurkDavid Mauleón
Jul 20, 2007·The Cochrane Database of Systematic Reviews·K WeilP Coulthard

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