Analgesic nephropathy in rodents

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
R G Schnellmann


While it is clear that humans suffer from "classic" analgesic nephropathy, the causative agents and mechanisms are still not known. A review of the literature revealed that chronic acetaminophen exposure does not produce renal papillary necrosis in rodents or humans. In contrast, while chronic aspirin exposure to rodents results in renal papillary necrosis with renal morphological and functional changes similar to that described in humans, epidemiological studies do not implicate aspirin alone in human analgesic nephropathy. The difference in the effects of aspirin in humans and rats may be due to the inability of epidemiological studies to detect aspirin-induced analgesic nephropathy or more likely to the fact that species differences exist, with the rat being more sensitive than humans. With respect to combinations of aspirin and acetaminophen, with or without caffeine, there are minimal tightly controlled studies. In addition, there is little evidence of enhanced renal papillary necrosis in rodents treated with aspirin and acetaminophen combinations. In summary, it remains to be determined what chemical entities cause "classic" analgesic nephropathy in humans and the mechanisms of this toxicity such that preventative measure...Continue Reading


Jan 1, 1978·Kidney International·J H Shelley
Jan 1, 1978·Kidney International·A Burry
Jan 1, 1978·Kidney International·E A Molland
Oct 1, 1976·CRC Critical Reviews in Toxicology·I Rosner
Feb 15, 1975·The Medical Journal of Australia·M A McIver
Mar 1, 1989·Toxicology Letters·N J GreggP H Bach
Oct 1, 1986·Toxicology and Applied Pharmacology·S L JohanssonS M Cohen
Jul 1, 1972·Pathology·R A Axelsen, A F Burry
Jan 1, 1973·Pathology·R A Axelsen
Nov 1, 1980·Kidney International·G G Duggin
Jan 1, 1980·Drug and Chemical Toxicology·A W Macklin, R J Szot
Jan 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W L HenrichG Eknoyan
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V D'Agati
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Sabatini
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V M Buckalew
Mar 21, 1998·Toxicologic Pathology·P H Bach, T K Nguyen
Aug 1, 1958·The Journal of Clinical Investigation·R SCHMIDR L SWARM

❮ Previous
Next ❯


Sep 9, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ana Andres-HernandoTomas Berl
Jan 7, 2003·Toxicologic Pathology·Amy E Brix
Nov 8, 2017·Alternatives to Laboratory Animals : ATLA·Lit-Hsin Loo, Daniele Zink

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.