PMID: 9164999May 1, 1997Paper

Analgesic response to stress is reduced in perinatally undernourished rats

The Journal of Nutrition
A C Gutiérrez, E A Keller

Abstract

Stress-induced analgesia was evaluated in adult rats submitted early in life to a protein deprivation schedule. Rats were undernourished with a hypoproteic diet containing 80 g casein/kg diet from d 14 of gestation until 50 days of age. Rats were thereafter fed a balanced nonpurified diet until 140 days of age, when they were exposed to two stressors: forced swimming and acute restraint, after which the analgesic response was evaluated. In addition, the analgesic response induced by different morphine doses was determined in another group of rats. Basal latency was not different in deprived and control rats. Undernourished rats presented a significantly lower analgesic response in both stress situations. However, when the analgesic response induced by different morphine doses (1, 2, 4 and 8 mg/kg, s.c.) was assessed, a significantly higher response occurred in undernourished rats compared to control rats. This lower stress-induced analgesia in undernourished rats may account for the behavioral alterations attributed to early undernutrition.

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Citations

Nov 19, 2008·Stress : the International Journal on the Biology of Stress·M TrzctńskaJ R Galler
Sep 12, 2009·Human & Experimental Toxicology·David Calderón-GuzmánHugo Juárez-Olguín
Apr 4, 2002·Nutritional Neuroscience·Silvia KademianElizabeth A Keller
Aug 31, 2010·Pain·Terry K Borsook, Geoff MacDonald
Apr 28, 2009·Progress in Neurobiology·Ryan K Butler, David P Finn

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