Analgesic safety and efficacy of diclofenac sodium softgels on postoperative third molar extraction pain

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
John R ZunigaCharles Bon

Abstract

The purpose of this single-blind, placebo-controlled, 3-arm parallel, randomized study was to compare the analgesic efficacy and tolerability of a single dose of 100 mg diclofenac potassium (Cataflam; Novartis, Stein, Switzerland), 100 mg diclofenac sodium softgel, and placebo in patients experiencing moderate to severe postoperative pain after third molar extraction. Seventy-five patients (67% female with a mean age of 23, age range 18 to 34.5 years) participated in the study following removal of at least 1 impacted mandibular third molar. Patients received a single dose of study medication when their postoperative pain reached a moderate or severe intensity. Analgesic efficacy measures included the time to meaningful pain relief measured using a stopwatch and time to rescue medication. Pain relief (PR) and Pain intensity (PI) ratings were recorded at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 8, and 24 hours postdosing. Summary analgesic measures, including Summed Pain Relief Score (TOTPAR) and Summed Pain Intensity Differences (SPID), were calculated from the 0.25- to 6-hour responses. The time between pain relief and rescue and a global evaluation for the effectiveness of the study medications were recorded at the end of the s...Continue Reading

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Jun 18, 2009·American Journal of Therapeutics·Mark KowalskiStephen E Boesing
Apr 26, 2007·Clinical Medicine & Research·C K S OngR A Seymour
Sep 2, 2010·Current Medical Research and Opinion·Stephen E DanielsStephen E Boesing
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Sep 25, 2014·American Journal of Therapeutics·Bill H McCarberg, Byron Cryer
Apr 7, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·R Andrew Moore, Sheena Derry

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